New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids
E Yu Yamansarov
1
,
D A Skvortsov
1
,
A. V. Lopukhov
1
,
S V Kovalev
1
,
S A Evteev
1
,
R A Petrov
1
,
N L Klyachko
1, 2
,
N. V. Zyk
1
,
E K Beloglazkina
1
,
Ya A Ivanenkov
3, 4
,
A G Majouga
1, 5, 6
3
Publication type: Journal Article
Publication date: 2019-12-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
New ligands for targeted delivery to the liver based on glycoconjugated natural triterpenoids are proposed. Simple chemical transformations of starting lupane triterpenes led to betulin or betulinic acid conjugates with N-acetyl-d-galactosamine linked through an isopropenyl fragment of the terpene skeleton. The obtained compounds were non-toxic in vitro to a series of cancer cell lines and normal cells. Molecular docking in silico and surface plasmon resonance spectroscopy revealed a high specificity of the synthesized glycotriterpenoids to the asialogly-coprotein receptor of hepatocytes.
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8
Total citations:
8
Citations from 2024:
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(25%)
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GOST
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Yamansarov E. Yu. et al. New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids // Russian Chemical Bulletin. 2019. Vol. 68. No. 12. pp. 2331-2338.
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Yamansarov E. Yu., Skvortsov D. A., Lopukhov A. V., Kovalev S. V., Evteev S. A., Petrov R. A., Klyachko N. L., Zyk N. V., Beloglazkina E. K., Ivanenkov Ya. A., Majouga A. G. New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids // Russian Chemical Bulletin. 2019. Vol. 68. No. 12. pp. 2331-2338.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s11172-019-2707-9
UR - http://link.springer.com/10.1007/s11172-019-2707-9
TI - New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids
T2 - Russian Chemical Bulletin
AU - Yamansarov, E Yu
AU - Skvortsov, D A
AU - Lopukhov, A. V.
AU - Kovalev, S V
AU - Evteev, S A
AU - Petrov, R A
AU - Klyachko, N L
AU - Zyk, N. V.
AU - Beloglazkina, E K
AU - Ivanenkov, Ya A
AU - Majouga, A G
PY - 2019
DA - 2019/12/01
PB - Springer Nature
SP - 2331-2338
IS - 12
VL - 68
SN - 1066-5285
SN - 1573-9171
ER -
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BibTex (up to 50 authors)
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@article{2019_Yamansarov,
author = {E Yu Yamansarov and D A Skvortsov and A. V. Lopukhov and S V Kovalev and S A Evteev and R A Petrov and N L Klyachko and N. V. Zyk and E K Beloglazkina and Ya A Ivanenkov and A G Majouga},
title = {New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids},
journal = {Russian Chemical Bulletin},
year = {2019},
volume = {68},
publisher = {Springer Nature},
month = {dec},
url = {http://link.springer.com/10.1007/s11172-019-2707-9},
number = {12},
pages = {2331--2338},
doi = {10.1007/s11172-019-2707-9}
}
Cite this
MLA
Copy
Yamansarov, E. Yu., et al. āNew ASGPR-targeted ligands based on glycoconjugated natural triterpenoids.ā Russian Chemical Bulletin, vol. 68, no. 12, Dec. 2019, pp. 2331-2338. http://link.springer.com/10.1007/s11172-019-2707-9.