Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents
S.N. Fedorov
1
,
A S Kuzmich
1
,
Yu E Sabutskii
1
,
A G Guzii
1
,
R. S. Popov
1
,
V A Ogurtsov
2
,
O A Rakitin
2, 3
,
S G Polonik
1
Тип публикации: Journal Article
Дата публикации: 2021-03-27
scimago Q3
БС2
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Краткое описание
Nucleophilic substitution of a chlorine atom in 4,5 dichloro-1,2-dithiole-3-thione with per- O -acetyl-1-mercaptho derivatives of d -glucose, d -galactose, d -mannose, d -xylose, l -arabinose, and d -maltose gave six new acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione. These thioglycosides were shown to possess cancer preventive activity on the models of JB6 Cl41 P + mouse epidermal cells and THP-1 human leukemia cells in soft agar, as well as to inhibit the AP-1-dependent transcriptional activity in JB6 Cl41 luc-AP-1 cells, which suggests the possibility of using the new compounds as potential cancer preventive drugs.
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Fedorov S. et al. Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents // Russian Chemical Bulletin. 2021. Vol. 70. No. 3. pp. 573-579.
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Fedorov S., Kuzmich A. S., Sabutskii Yu. E., Guzii A. G., Popov R. S., Ogurtsov V. A., Rakitin O. A., Polonik S. G. Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents // Russian Chemical Bulletin. 2021. Vol. 70. No. 3. pp. 573-579.
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TY - JOUR
DO - 10.1007/s11172-021-3127-1
UR - https://doi.org/10.1007/s11172-021-3127-1
TI - Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents
T2 - Russian Chemical Bulletin
AU - Fedorov, S.N.
AU - Kuzmich, A S
AU - Sabutskii, Yu E
AU - Guzii, A G
AU - Popov, R. S.
AU - Ogurtsov, V A
AU - Rakitin, O A
AU - Polonik, S G
PY - 2021
DA - 2021/03/27
PB - Springer Nature
SP - 573-579
IS - 3
VL - 70
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2021_Fedorov,
author = {S.N. Fedorov and A S Kuzmich and Yu E Sabutskii and A G Guzii and R. S. Popov and V A Ogurtsov and O A Rakitin and S G Polonik},
title = {Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents},
journal = {Russian Chemical Bulletin},
year = {2021},
volume = {70},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1007/s11172-021-3127-1},
number = {3},
pages = {573--579},
doi = {10.1007/s11172-021-3127-1}
}
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MLA
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Fedorov, S.N., et al. “Synthesis and studies of acetylthioglycoside conjugates of 4-chloro-1,2-dithiole-3-thione as potential antitumor agents.” Russian Chemical Bulletin, vol. 70, no. 3, Mar. 2021, pp. 573-579. https://doi.org/10.1007/s11172-021-3127-1.
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