Springer Nature
Russian Chemical Bulletin
,  volume 71 ,  issue 3 ,  pages 489-495

Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo

Publication type: Journal Article
Publication date: 2022-03-01
Springer Nature
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
Nucleophilic substitution of the chlorine atom in 4,5-dichloro-1,2-dithiol-3-one using 1-thio-β-d-glucopyranose and its 2,3,4,6-tetra-O-acetyl derivative in acetonitrile resulted in two new 5-thioglucoside conjugates of 4-chloro-1,2-dithiol-3-one. The obtained thioglucosides showed cancer-preventive properties in a model of mouse epidermal JB6Cl41 P+ cells in soft agar, while one of them manifested antitumor activity in in vivo experiments in CD1 mice on a model of solid Ehrlich carcinoma. Both compounds were shown to inhibit basic AP-1-dependent transcriptional activity in murine JB6 Cl41 luc-AP-1 cells.
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GOST Copy
Fedorov S. et al. Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo // Russian Chemical Bulletin. 2022. Vol. 71. No. 3. pp. 489-495.
GOST all authors (up to 50) Copy
Fedorov S., Kuzmich A. S., Agafonova I., Sabutskii Yu. E., Guzii A. G., Popov R. S., Ogurtsov V. A., Rakitin O. A., Polonik S. G. Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo // Russian Chemical Bulletin. 2022. Vol. 71. No. 3. pp. 489-495.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1007/s11172-022-3438-x
UR - https://doi.org/10.1007/s11172-022-3438-x
TI - Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo
T2 - Russian Chemical Bulletin
AU - Fedorov, S.N.
AU - Kuzmich, A S
AU - Agafonova, I.G.
AU - Sabutskii, Yu E
AU - Guzii, A G
AU - Popov, R. S.
AU - Ogurtsov, V A
AU - Rakitin, O A
AU - Polonik, S G
PY - 2022
DA - 2022/03/01
PB - Springer Nature
SP - 489-495
IS - 3
VL - 71
SN - 1066-5285
SN - 1573-9171
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Fedorov,
author = {S.N. Fedorov and A S Kuzmich and I.G. Agafonova and Yu E Sabutskii and A G Guzii and R. S. Popov and V A Ogurtsov and O A Rakitin and S G Polonik},
title = {Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo},
journal = {Russian Chemical Bulletin},
year = {2022},
volume = {71},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1007/s11172-022-3438-x},
number = {3},
pages = {489--495},
doi = {10.1007/s11172-022-3438-x}
}
MLA
Cite this
MLA Copy
Fedorov, S.N., et al. “Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo.” Russian Chemical Bulletin, vol. 71, no. 3, Mar. 2022, pp. 489-495. https://doi.org/10.1007/s11172-022-3438-x.