Synthesis of 3,5-difuroxanyl-1,6-dihydro-1,2,4-triazines

An approach for the synthesis of the first representatives of 3,5-difuroxanyl-1,6-di-hydro-1,2,4-triazines based on the reaction of (furoxanyl)amidrazones with 4-amino-3-bromoacetylfuroxan under mild conditions was proposed. It was shown that the reaction proceeds via initial alkylation of the starting amidrazones with bromoacetylfuroxan followed by the intramolecular condensation with the formation of dihydro-1,2,4-triazine ring. Attempts to oxidize synthesized heterocyclic systems to fully aromatic derivatives under various conditions were performed.