, volume 14 , issue 4 , publication number 473

Sulfonylureas: A New Look at Old Therapy

Peter M. Thulé ^{1, 2}

Guillermo Umpierrez ²

Hide authors affiliations Show authors affiliations: 2 affiliations

Section Endocrinology and Metabolism, Atlanta VA Medical Center, Atlanta, USA |

Division of Endocrinology, Diabetes, and Lipids, Department of Medicine, Emory University School of Medicine, Decatur, USA |

Publication type: Journal Article

Publication date: 2014-02-22

Springer Nature

Current Diabetes Reports

scimago Q1

wos Q1

SJR: 2.163

CiteScore: 12.0

Impact factor: 6.4

ISSN: 15344827, 15390829

DOI: 10.1007/s11892-014-0473-5

Copy DOI

PubMed ID: 24563333

Endocrinology, Diabetes and Metabolism

Internal Medicine

Abstract

Sulfonylurea compounds were the first available oral antidiabetic agents and they remain an important tool in our quest for optimal glucose control. The sulfonylureas stimulate the release of insulin from pancreatic β-cells and have a number of extrapancreatic effects, including decreasing hepatic insulin clearance and reducing glucagon secretion in patients with type 2 diabetes. Although these agents have been the mainstay of pharmacotherapy for patients with type 2 diabetes mellitus (T2DM), their safety and clinical utility has been a matter of active debate in recent years, as their use is associated with risks of hypoglycemia and weight gain. We review the discovery and mechanisms of action of sulfonylureas, and the results of clinical trials to provide practical information on the pros and cons of their use in clinical practice. This review addresses advances in our understanding of mechanisms of action of sulfonylurea agents, their efficacy in T2DM, side effects, and impact on cardiovascular disease outcomes.

Found

1 citation

Arkhipov Sergey

39 publications, 313 citations

h-index: 11

Boreskov Institute of Catalysis of the Siberian Branch of the Russian Academy of Sciences

1 citation

Gaynanova Gulnara

PhD in Chemistry

74 publications, 1 072 citations, 1 review

h-index: 18

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Supramolecular chemistry

Surfactants

1 citation

Rychkov Denis

🥼

PhD in Chemistry

35 publications, 422 citations, 22 reviews

h-index: 14

Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the Russian Academy of Sciences

Novosibirsk State University

Research interests

Computational methods in chemistry

Crystallography

Density functional theory (DFT)

High pressures

Management in science

Polymorphism

Quantum Chemistry

1 citation

Vasilyeva Leysan

PhD in Chemistry

29 publications, 491 citations

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Surfactants

1 citation

Zakharova Lucia

DSc in Chemistry, professor

394 publications, 6 163 citations

h-index: 36

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

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