Applied Biochemistry and Biotechnology
Exploring the Potential of a Herbal Nanoemulsion as an Antimicrobial Mouthwash
Publication type: Journal Article
Publication date: 2023-01-28
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3
ISSN: 02732289, 15590291
Biochemistry
Molecular Biology
General Medicine
Applied Microbiology and Biotechnology
Biotechnology
Bioengineering
Abstract
The study aimed to formulate a nanoemulsion, combine it with aqueous extracts of herbal powders, and test its efficiency as caries-preventing mouthwash. Formulation of nanoemulsion using microfluidizer, characterization of nanoemulsion, minimum inhibitory concentration, adherence test, biofilm assay, and artificial mouth assay was carried out. The biofilms of Streptococcus mutans, Lactobacillus casei, Actinomyces viscosus, and a combination of the three cultures were developed and treated with formulations to study the inhibitory effect of the samples. In artificial mouth assay, human tooth samples were used as surfaces to grow the biofilm of S. mutans, and daily, the teeth were treated with the formulations to test their real-time efficiency. The nanoemulsion was characterized using dynamic light scattering and the size of the particles was within the 100–300 nm range. Above 50 °C, the nanoemulsion combined with plant extract lost its emulsified state within 2 h of incubation, while the nanoemulsion was stable. Nanoemulsion with plant extract inhibited the adherence of L. casei (73%) and biofilm of L. casei (66%). In artificial mouth assay, after 10 days of nanoemulsion, nanoemulsion with plant extract showed DIAGNOdent pen values 3.5 and 2 respectively whereas the negative control value was 14.4 indicating caries initiation. The nanoemulsion with plant extract showed anti-adherence and anti-biofilm activity and hence can be used as a potent anticariogenic mouthwash.
Top-30
Citations by journals
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1
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Russian Chemical Reviews
1 publication, 50%
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Current Issues in Molecular Biology
1 publication, 50%
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1
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Citations by publishers
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1
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 50%
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 50%
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1
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nehavarshini V., Unnikrishnan S., Ramalingam K. Exploring the Potential of a Herbal Nanoemulsion as an Antimicrobial Mouthwash // Applied Biochemistry and Biotechnology. 2023.
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Nehavarshini V., Unnikrishnan S., Ramalingam K. Exploring the Potential of a Herbal Nanoemulsion as an Antimicrobial Mouthwash // Applied Biochemistry and Biotechnology. 2023.
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TY - JOUR
DO - 10.1007/s12010-023-04356-6
UR - https://doi.org/10.1007/s12010-023-04356-6
TI - Exploring the Potential of a Herbal Nanoemulsion as an Antimicrobial Mouthwash
T2 - Applied Biochemistry and Biotechnology
AU - Nehavarshini, V.
AU - Unnikrishnan, Sneha
AU - Ramalingam, Karthikeyan
PY - 2023
DA - 2023/01/28 00:00:00
PB - Springer Nature
SN - 0273-2289
SN - 1559-0291
ER -
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@article{2023_Nehavarshini,
author = {V. Nehavarshini and Sneha Unnikrishnan and Karthikeyan Ramalingam},
title = {Exploring the Potential of a Herbal Nanoemulsion as an Antimicrobial Mouthwash},
journal = {Applied Biochemistry and Biotechnology},
year = {2023},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007/s12010-023-04356-6},
doi = {10.1007/s12010-023-04356-6}
}