Biomolecular NMR Assignments, том 10, издание 1, номера страниц: 183-187

NMR assignments of the N-terminal domain of Ogataea polymorpha telomerase reverse transcriptase

Тип документаJournal Article
Дата публикации2015-12-31
ИздательSpringer Nature
Название журналаBiomolecular NMR Assignments
Квартиль по SCImagoQ4
Квартиль по Web of ScienceQ4
Импакт-фактор 20210.73
ISSN18742718, 1874270X
Biochemistry
Structural Biology
Краткое описание
Telomerase is a ribonucleoprotein enzyme that adds telomeric DNA fragments to the ends of chromosomes. This enzyme is the focus of substantial attention, both because its structure and mechanism of action are still poorly studied, and because of its pivotal roles in aging and cellular proliferation. The use of telomerase as a potential target for the design of new anticancer drugs is also of great interest. The catalytic protein subunit of telomerase (TERT) contains an N-terminal domain (TEN) that is essential for activity and processivity. Elucidation of the structure and dynamics of TEN in solution is important for understanding the molecular mechanism of telomerase activity and for the design of new telomerase inhibitors. To approach this problem, in this study we report the 1H, 13C, and 15N chemical shift assignments of TEN from Ogataea polymorpha. Analysis of the assigned chemical shifts allowed us to identify secondary structures and protein regions potentially involved in interaction with other participants of the telomerase catalytic cycle.
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1. Polshakov V.I. и др. NMR assignments of the N-terminal domain of Ogataea polymorpha telomerase reverse transcriptase // Biomolecular NMR Assignments. 2015. Т. 10. № 1. С. 183–187.
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TY - JOUR

DO - 10.1007/s12104-015-9663-6

UR - http://dx.doi.org/10.1007/s12104-015-9663-6

TI - NMR assignments of the N-terminal domain of Ogataea polymorpha telomerase reverse transcriptase

T2 - Biomolecular NMR Assignments

AU - Polshakov, Vladimir I.

AU - Petrova, Olga A.

AU - Parfenova, Yulia Yu.

AU - Efimov, Sergey V.

AU - Klochkov, Vladimir V.

AU - Zvereva, Maria I.

AU - Dontsova, Olga A.

PY - 2015

DA - 2015/12/31

PB - Springer Science and Business Media LLC

SP - 183-187

IS - 1

VL - 10

SN - 1874-2718

SN - 1874-270X

ER -

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@article{2015,

doi = {10.1007/s12104-015-9663-6},

url = {https://doi.org/10.1007%2Fs12104-015-9663-6},

year = 2015,

month = {dec},

publisher = {Springer Science and Business Media {LLC}},

volume = {10},

number = {1},

pages = {183--187},

author = {Vladimir I. Polshakov and Olga A. Petrova and Yulia Yu. Parfenova and Sergey V. Efimov and Vladimir V. Klochkov and Maria I. Zvereva and Olga A. Dontsova},

title = {{NMR} assignments of the N-terminal domain of Ogataea polymorpha telomerase reverse transcriptase}

}

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Polshakov, Vladimir I. et al. “NMR Assignments of the N-Terminal Domain of Ogataea Polymorpha Telomerase Reverse Transcriptase.” Biomolecular NMR Assignments 10.1 (2015): 183–187. Crossref. Web.