Biomolecular NMR Assignments, том 12, издание 2, номера страниц: 303-308

NMR assignments of the WBSCR27 protein related to Williams-Beuren syndrome

Petrova Olga A. 3
Osterman Ilya A. 2, 3, 4
Sergeeva Olga V. 4
Efimov Sergey V. 5
Klochkov Vladimir V. 5
Sergiev Petr V. 2, 3, 4
Dontsova Olga A. 2, 3, 4
Huang Tai-huang 6
Chang Chi-Fon 7
Тип документаJournal Article
Дата публикации2018-06-04
ИздательSpringer Nature
Название журналаBiomolecular NMR Assignments
Квартиль по SCImagoQ4
Квартиль по Web of ScienceQ4
Импакт-фактор 20210.73
ISSN18742718, 1874270X
Structural Biology
Краткое описание
Williams-Beuren syndrome is a genetic disorder characterized by physiological and mental abnormalities, and is caused by hemizygous deletion of several genes in chromosome 7. One of the removed genes encodes the WBSCR27 protein. Bioinformatic analysis of the sequence of WBSCR27 indicates that it belongs to the family of SAM-dependent methyltransferases. However, exact cellular functions of this protein or phenotypic consequences of its deficiency are still unknown. Here we report nearly complete 1H, 15N, and 13C chemical shifts assignments of the 26 kDa WBSCR27 protein from Mus musculus in complex with the cofactor S-adenosyl-l-methionine (SAM). Analysis of the assigned chemical shifts allowed us to characterize the protein’s secondary structure and backbone dynamics. The topology of the protein’s fold confirms the assumption that the WBSCR27 protein belongs to the family of class I methyltransferases.
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1. Mariasina S.S. и др. NMR assignments of the WBSCR27 protein related to Williams-Beuren syndrome // Biomolecular NMR Assignments. 2018. Т. 12. № 2. С. 303–308.


DO - 10.1007/s12104-018-9827-2

UR -

TI - NMR assignments of the WBSCR27 protein related to Williams-Beuren syndrome

T2 - Biomolecular NMR Assignments

AU - Mariasina, Sofia S.

AU - Petrova, Olga A.

AU - Osterman, Ilya A.

AU - Sergeeva, Olga V.

AU - Efimov, Sergey V.

AU - Klochkov, Vladimir V.

AU - Sergiev, Petr V.

AU - Dontsova, Olga A.

AU - Huang, Tai-huang

AU - Chang, Chi-Fon

AU - Polshakov, Vladimir I.

PY - 2018

DA - 2018/06/04

PB - Springer Science and Business Media LLC

SP - 303-308

IS - 2

VL - 12

SN - 1874-2718

SN - 1874-270X

ER -

BibTex |


doi = {10.1007/s12104-018-9827-2},

url = {},

year = 2018,

month = {jun},

publisher = {Springer Science and Business Media {LLC}},

volume = {12},

number = {2},

pages = {303--308},

author = {Sofia S. Mariasina and Olga A. Petrova and Ilya A. Osterman and Olga V. Sergeeva and Sergey V. Efimov and Vladimir V. Klochkov and Petr V. Sergiev and Olga A. Dontsova and Tai-huang Huang and Chi-Fon Chang and Vladimir I. Polshakov},

title = {{NMR} assignments of the {WBSCR}27 protein related to Williams-Beuren syndrome}


Mariasina, Sofia S. et al. “NMR Assignments of the WBSCR27 Protein Related to Williams-Beuren Syndrome.” Biomolecular NMR Assignments 12.2 (2018): 303–308. Crossref. Web.