BioNanoScience, volume 8, issue 1, pages 394-406
Effect of Iron Oxide Nanoparticle Shape on Doxorubicin Drug Delivery Toward LNCaP and PC-3 Cell Lines
Nizamov T R
1
,
Garanina A S
1, 2
,
Grebennikov I S
1
,
Zhironkina O A
3
,
Strelkova O S
3
,
Alieva I. B.
3
,
Kireev I I
3
,
Abakumov M A
1, 4
,
Savchenko A G
1
,
Majouga A G
1, 2, 5
3
Publication type: Journal Article
Publication date: 2018-02-09
Journal:
BioNanoScience
Quartile SCImago
Q3
Quartile WOS
—
Impact factor: 2.9
ISSN: 21911630, 21911649
Bioengineering
Biomedical Engineering
Abstract
In this paper, we investigated the delivery efficiency of doxorubicin by magnetite nanoparticles with different shape to LNCaP and PC-3 prostate cancer cell lines. Cubic and spherical nanoparticles of magnetite were synthesized in organic medium and hydrophilized by non-ionic surfactant Pluronic F127—polyethylene-polypropylene oxide polymer. Doxorubicin was loaded into hydrophobic region of polymeric shell. We have observed that cytotoxicity and distribution of doxorubicin in cells changed significantly in case of drug loaded into nanoparticles in comparison with free doxorubicin. We have shown that this change is due to two main reasons: (1) slower internalization of nanoparticles by cells compared to free doxorubicin and (2) slow and incomplete release of doxorubicin from nanoparticle polymer shell. Interestingly, nanoparticle shape influenced cytotoxicity and the dynamics of drug accumulation inside cancer cells. We have found that doxorubicin-loaded cubic nanoparticles were more toxic for both cell lines compared to spherical ones. Moreover, doxorubicin from cubic nanoparticles accumulated in cells faster than the drug loaded in spherical nanoparticles. So, our work shows that for efficient drug delivery, not only size and coating should be taken into account but also the shape of initial core as it plays an important role in nanoparticle interaction with cells.
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IGI Global
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IGI Global
1 publication, 8.33%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nizamov T. R. et al. Effect of Iron Oxide Nanoparticle Shape on Doxorubicin Drug Delivery Toward LNCaP and PC-3 Cell Lines // BioNanoScience. 2018. Vol. 8. No. 1. pp. 394-406.
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Nizamov T. R., Garanina A. S., Grebennikov I. S., Zhironkina O. A., Strelkova O. S., Alieva I. B., Kireev I. I., Abakumov M. A., Savchenko A. G., Majouga A. G. Effect of Iron Oxide Nanoparticle Shape on Doxorubicin Drug Delivery Toward LNCaP and PC-3 Cell Lines // BioNanoScience. 2018. Vol. 8. No. 1. pp. 394-406.
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TY - JOUR
DO - 10.1007/s12668-018-0502-y
UR - https://doi.org/10.1007%2Fs12668-018-0502-y
TI - Effect of Iron Oxide Nanoparticle Shape on Doxorubicin Drug Delivery Toward LNCaP and PC-3 Cell Lines
T2 - BioNanoScience
AU - Grebennikov, I S
AU - Garanina, A S
AU - Zhironkina, O A
AU - Strelkova, O S
AU - Alieva, I. B.
AU - Kireev, I I
AU - Majouga, A G
AU - Abakumov, M A
AU - Nizamov, T R
AU - Savchenko, A G
PY - 2018
DA - 2018/02/09 00:00:00
PB - Springer Nature
SP - 394-406
IS - 1
VL - 8
SN - 2191-1630
SN - 2191-1649
ER -
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@article{2018_Nizamov,
author = {I S Grebennikov and A S Garanina and O A Zhironkina and O S Strelkova and I. B. Alieva and I I Kireev and A G Majouga and M A Abakumov and T R Nizamov and A G Savchenko},
title = {Effect of Iron Oxide Nanoparticle Shape on Doxorubicin Drug Delivery Toward LNCaP and PC-3 Cell Lines},
journal = {BioNanoScience},
year = {2018},
volume = {8},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007%2Fs12668-018-0502-y},
number = {1},
pages = {394--406},
doi = {10.1007/s12668-018-0502-y}
}
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MLA
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Nizamov, T. R., et al. “Effect of Iron Oxide Nanoparticle Shape on Doxorubicin Drug Delivery Toward LNCaP and PC-3 Cell Lines.” BioNanoScience, vol. 8, no. 1, Feb. 2018, pp. 394-406. https://doi.org/10.1007%2Fs12668-018-0502-y.