Biological Activity of Bicyclic Monoterpene Alcohols
Liliya E Nikitina
1, 2
,
Svetlana A. Lisovskaya
1, 2, 3
,
Valeriya A Startseva
1
,
Larisa L. Frolova
4
,
Alexander V Kutchin
4
,
Olga V Ostolopovskaya
1, 2
,
Roman S Pavelyev
2
,
Mohammed A Khelkhal
2
,
Ilmir R Gilfanov
1
,
Inna V Fedyunina
1
,
Renad R Khaliullin
1
,
Rustem F Akhverdiev
6
,
Alexander V Gerasimov
6
,
Ekaterina V Abzaldinova
6
,
Alexander G Izmailov
1
Publication type: Journal Article
Publication date: 2021-10-14
scimago Q3
wos Q3
SJR: 0.488
CiteScore: 4.5
Impact factor: 3.2
ISSN: 21911630, 21911649
Bioengineering
Biomedical Engineering
Abstract
The present paper aims to study the biological properties of a series of bicyclic monoterpene alcohols. Firstly, we tested the obtained compounds for fungicidal activity against clinical and reference strains of microscopic fungi. Next, we determined the minimum inhibitory concentration of these compounds comparing to other drugs widely used in practical medicine (fluconazole, terbinafine). At this stage, we found that ( −)-myrtenol (47 MIC and 23.5 μg/ml) exhibits the most promising activity against filamentous and yeast fungi, respectively. Then, we have studied the membrane-protective and antioxidant activities of the obtained compounds and found out that ( −)-cis-verbenol and ( −)-myrtenol exhibit the highest activity on the model of erythrocytes oxidative hemolysis. Interestingly, among all the studied bicyclic monoterpene alcohols, the alcohols of the pinane series have been found to be the most promising. The obtained results from the present study suggest that ( −)-myrtenol would be a leading compound for further studies in terms of possible practical application.
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Metrics
16
Total citations:
16
Citations from 2025:
3
(18.75%)
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MLA
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GOST
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Nikitina L. E. et al. Biological Activity of Bicyclic Monoterpene Alcohols // BioNanoScience. 2021. Vol. 11. No. 4. pp. 970-976.
GOST all authors (up to 50)
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Nikitina L. E., Lisovskaya S. A., Startseva V. A., Frolova L. L., Kutchin A. V., Shevchenko O. G., Ostolopovskaya O. V., Pavelyev R. S., Khelkhal M. A., Gilfanov I. R., Fedyunina I. V., Khaliullin R. R., Akhverdiev R. F., Gerasimov A. V., Abzaldinova E. V., Izmailov A. G. Biological Activity of Bicyclic Monoterpene Alcohols // BioNanoScience. 2021. Vol. 11. No. 4. pp. 970-976.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s12668-021-00912-8
UR - https://doi.org/10.1007/s12668-021-00912-8
TI - Biological Activity of Bicyclic Monoterpene Alcohols
T2 - BioNanoScience
AU - Nikitina, Liliya E
AU - Lisovskaya, Svetlana A.
AU - Startseva, Valeriya A
AU - Frolova, Larisa L.
AU - Kutchin, Alexander V
AU - Shevchenko, Oksana G.
AU - Ostolopovskaya, Olga V
AU - Pavelyev, Roman S
AU - Khelkhal, Mohammed A
AU - Gilfanov, Ilmir R
AU - Fedyunina, Inna V
AU - Khaliullin, Renad R
AU - Akhverdiev, Rustem F
AU - Gerasimov, Alexander V
AU - Abzaldinova, Ekaterina V
AU - Izmailov, Alexander G
PY - 2021
DA - 2021/10/14
PB - Springer Nature
SP - 970-976
IS - 4
VL - 11
SN - 2191-1630
SN - 2191-1649
ER -
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BibTex (up to 50 authors)
Copy
@article{2021_Nikitina,
author = {Liliya E Nikitina and Svetlana A. Lisovskaya and Valeriya A Startseva and Larisa L. Frolova and Alexander V Kutchin and Oksana G. Shevchenko and Olga V Ostolopovskaya and Roman S Pavelyev and Mohammed A Khelkhal and Ilmir R Gilfanov and Inna V Fedyunina and Renad R Khaliullin and Rustem F Akhverdiev and Alexander V Gerasimov and Ekaterina V Abzaldinova and Alexander G Izmailov},
title = {Biological Activity of Bicyclic Monoterpene Alcohols},
journal = {BioNanoScience},
year = {2021},
volume = {11},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/s12668-021-00912-8},
number = {4},
pages = {970--976},
doi = {10.1007/s12668-021-00912-8}
}
Cite this
MLA
Copy
Nikitina, Liliya E., et al. “Biological Activity of Bicyclic Monoterpene Alcohols.” BioNanoScience, vol. 11, no. 4, Oct. 2021, pp. 970-976. https://doi.org/10.1007/s12668-021-00912-8.
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