Springer Nature
Drug Delivery and Translational Research
,  volume 11 ,  issue 1 ,  pages 292-304

Levofloxacin nanoemulsion gel has a powerful healing effect on infected wound in streptozotocin-induced diabetic rats

Alireza Valizadeh 1
, 
Mahdieh Shirzad 2
, 
Mohammad Reza Pourmand 3
, 
Maryam Farahmandfar 4
, 
Hassan Sereshti 5
, 
Amir Amani 1, 6, 7
1
 
2
 
3
 
4
 
5
 
6
 
7
 
Publication type: Journal Article
Publication date: 2020-06-11
Springer Nature
scimago Q1
wos Q1
SJR: 1.175
CiteScore: 12.7
Impact factor: 5.5
ISSN: 2190393X, 21903948
Pharmaceutical Science
Abstract
The aim of this study was to develop a novel oil-in-water (o/w) nanoemulsion gel containing levofloxacin for enhanced topical efficacy. Average particle size of sesame oil nanoemulsion without (SONE) and containing levofloxacin (SONEL) was found as 25.2 and 26.3 nm, respectively. Results from scratch test showed that SONEL had better proliferation effect in comparison with negative control. Treated animals with SONEL showed significant reduction in period of epithelialization, wound contraction, and number of inflammatory cells among all groups. Also, SONEL-treated group had the greatest collagen synthesis. Immunohistochemical analysis showed high intensity of CD31 and TGF-β at wound site of treatment groups with SONEL on day 12 post-treatment (P < 0.05). Skin irritation test demonstrated safety of SONEL gel for skin topical application. In conclusion, our studies suggest that SONEL could be an effective formulation for treatment of diabetic wound infection by controlling infection and improving the healing process.
Found 
Found 
1 citation
Gaynanova Gulnara
PhD in Chemistry
74 publications,  1 072 citations,  1 review
h-index: 18
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
Research interests
Colloidal chemistry
Drug delivery systems
Physical Chemistry
Supramolecular chemistry
Surfactants
1 citation
Vasilyeva Leysan
PhD in Chemistry
29 publications,  491 citations
h-index: 14
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
Research interests
Colloidal chemistry
Drug delivery systems
Physical Chemistry
Surfactants
1 citation
Zakharova Lucia
DSc in Chemistry, professor
394 publications,  6 163 citations
h-index: 36
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
1 citation
Emran Talha
559 publications,  18 760 citations,  7 343 reviews
h-index: 67
Brown University
Brown University
BGC Trust University Bangladesh
BGC Trust University Bangladesh
Research interests
Bioinformatics
Immunology

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GOST Copy
Valizadeh A. et al. Levofloxacin nanoemulsion gel has a powerful healing effect on infected wound in streptozotocin-induced diabetic rats // Drug Delivery and Translational Research. 2020. Vol. 11. No. 1. pp. 292-304.
GOST all authors (up to 50) Copy
Valizadeh A., Shirzad M., Pourmand M. R., Farahmandfar M., Sereshti H., Amani A. Levofloxacin nanoemulsion gel has a powerful healing effect on infected wound in streptozotocin-induced diabetic rats // Drug Delivery and Translational Research. 2020. Vol. 11. No. 1. pp. 292-304.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1007/s13346-020-00794-5
UR - https://doi.org/10.1007/s13346-020-00794-5
TI - Levofloxacin nanoemulsion gel has a powerful healing effect on infected wound in streptozotocin-induced diabetic rats
T2 - Drug Delivery and Translational Research
AU - Valizadeh, Alireza
AU - Shirzad, Mahdieh
AU - Pourmand, Mohammad Reza
AU - Farahmandfar, Maryam
AU - Sereshti, Hassan
AU - Amani, Amir
PY - 2020
DA - 2020/06/11
PB - Springer Nature
SP - 292-304
IS - 1
VL - 11
PMID - 32529392
SN - 2190-393X
SN - 2190-3948
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2020_Valizadeh,
author = {Alireza Valizadeh and Mahdieh Shirzad and Mohammad Reza Pourmand and Maryam Farahmandfar and Hassan Sereshti and Amir Amani},
title = {Levofloxacin nanoemulsion gel has a powerful healing effect on infected wound in streptozotocin-induced diabetic rats},
journal = {Drug Delivery and Translational Research},
year = {2020},
volume = {11},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1007/s13346-020-00794-5},
number = {1},
pages = {292--304},
doi = {10.1007/s13346-020-00794-5}
}
MLA
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MLA Copy
Valizadeh, Alireza, et al. “Levofloxacin nanoemulsion gel has a powerful healing effect on infected wound in streptozotocin-induced diabetic rats.” Drug Delivery and Translational Research, vol. 11, no. 1, Jun. 2020, pp. 292-304. https://doi.org/10.1007/s13346-020-00794-5.