Clinical Nutrition

, volume 11 , issue 5 , pages 289-297

Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake

H Carrstensen ¹

R. Dietmar Müller ¹

B Müller ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Pharmaceutics and Biopharmaceutics, University of Kiel, Gutenbergstrasse 76-78, D-2300 Kiel, Germany. |

Publication type: Journal Article

Publication date: 1992-10-01

Elsevier

Clinical Nutrition

scimago Q1

wos Q1

SJR: 2.212

CiteScore: 15.5

Impact factor: 7.4

ISSN: 02615614, 15321983

DOI: 10.1016/0261-5614(92)90006-c

Copy DOI

PubMed ID: 16840011

Nutrition and Dietetics

Critical Care and Intensive Care Medicine

Abstract

Fat emulsions for parenteral nutrition, stabilized by egg lecithin, were characterized in terms of parameters relevant to uptake by the reticuloendothelial system (RES), e.g. size distribution, surface hydrophobicity and adsorption of serum components as a measure of the degree of opsonization. Adsorption of serum components was quantified by zeta potential measurement. Fat emulsions for nutrition were compared with emulsions used for drug delivery and model drug carries for intravenous injection. The emulsions for drug delivery were stabilized by the blockcopolymers Poloxamer 188 and 407 (Pluronic F68 and F127) and Poloxamine 908. Model drug carriers were hydrophobic and hydrophilic polystyrene latex particles. Hydrophilic particles were prepared by adsorption of Poloxamine 908 (coating) onto the particle surface. The hydrophobicity and serum protein adsorption decreased from hydrophobic latex particles to egg lecithin emulsions and blockcopolymer emulsions and particles. The data correlated with that in the literature concerning liver uptake in vivo showing complete RES clearance of hydrophobic latex particles, reduced uptake of egg lecithin emulsions and avoidance of RES uptake by Poloxamine 908 coated particles.

Found

1 citation

Gaynanova Gulnara

PhD in Chemistry

74 publications, 1 073 citations, 1 review

h-index: 18

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Supramolecular chemistry

Surfactants

1 citation

Vasilyeva Leysan

PhD in Chemistry

29 publications, 492 citations

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Surfactants

1 citation

Zakharova Lucia

DSc in Chemistry, professor

394 publications, 6 176 citations

h-index: 37

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

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Carrstensen H., Müller R. D., Müller B. Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake // Clinical Nutrition. 1992. Vol. 11. No. 5. pp. 289-297.

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RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/0261-5614(92)90006-c

UR - https://doi.org/10.1016/0261-5614(92)90006-c

TI - Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake

T2 - Clinical Nutrition

AU - Carrstensen, H

AU - Müller, R. Dietmar

AU - Müller, B

PY - 1992

DA - 1992/10/01

PB - Elsevier

SP - 289-297

IS - 5

VL - 11

PMID - 16840011

SN - 0261-5614

SN - 1532-1983

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{1992_Carrstensen,

author = {H Carrstensen and R. Dietmar Müller and B Müller},

title = {Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake},

journal = {Clinical Nutrition},

year = {1992},

volume = {11},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016/0261-5614(92)90006-c},

number = {5},

pages = {289--297},

doi = {10.1016/0261-5614(92)90006-c}

}

MLA

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MLA Copy

Carrstensen, H., et al. “Particle size, surface hydrophobicity and interaction with serum of parenteral fat emulsions and model drug carriers as parameters related to RES uptake.” Clinical Nutrition, vol. 11, no. 5, Oct. 1992, pp. 289-297. https://doi.org/10.1016/0261-5614(92)90006-c.

Publisher

Elsevier

Journal

Clinical Nutrition

scimago Q1

wos Q1

SJR

2.212

CiteScore

15.5

Impact factor

7.4

ISSN

02615614 (Print)

15321983 (Electronic)