[9-14C]fluorene hydroperoxide as a possible intermediate in the hydroxylation of [9-3C]fluorene by rat liver homogenate
Publication type: Journal Article
Publication date: 1969-09-01
scimago Q2
wos Q3
SJR: 0.767
CiteScore: 5.8
Impact factor: 2.2
ISSN: 00063002, 03044165, 18728006, 18782434
PubMed ID:
5821026
Biochemistry
Molecular Biology
Biophysics
Abstract
1. 1 [9- 14 C]-fluorene was chosen as substrate to study the mechanism of biological oxygenation. Both fluorene and fluorene hydroperoxide were converted to fluorenol by rat liver supernatant fraction obtained at 10 000 × g . When the liver enzyme was bolied, it no longer converted fluorene to fluorenol; however, it converted fluorene hydroperoxide to fluorenol at 36% of the activity of actiev unheated enzyme. 2. 2. The pretreatment of rats with fluorene doubled the enzymatic activity for the conversion of fluorene to fluorenol, whereas phenobarbital increased activity to 5-fold as compared to control. 3. 3. Radioactive fluorene hydroperoxide has been identified in reaction mixtures hydroxylating [9- 14 C]fluorene. An incorporation yield of 4.8% of [9- 14 C]fluorene hydroperoxide from [9- 14 C]fluorene was obtained. The radioactive fluorene hydroperoxide was isolated, converted into fluorenone and the phenylhydrazone. The identity and purity was confirmed by thin-layer chromatography, by ultraviolet spectra and by specific determination. 4. 4 The findings indicated that [9- 14 C]fluorene hydroperoxide can be an intermediate in the hydroxylation of [9- 14 C]fluorene by rat liver homogenate.
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GOST
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Chen C., Lin C. [9-14C]fluorene hydroperoxide as a possible intermediate in the hydroxylation of [9-3C]fluorene by rat liver homogenate // Biochimica et Biophysica Acta - General Subjects. 1969. Vol. 184. No. 3. pp. 634-640.
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Chen C., Lin C. [9-14C]fluorene hydroperoxide as a possible intermediate in the hydroxylation of [9-3C]fluorene by rat liver homogenate // Biochimica et Biophysica Acta - General Subjects. 1969. Vol. 184. No. 3. pp. 634-640.
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RIS
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TY - JOUR
DO - 10.1016/0304-4165(69)90278-5
UR - https://doi.org/10.1016/0304-4165(69)90278-5
TI - [9-14C]fluorene hydroperoxide as a possible intermediate in the hydroxylation of [9-3C]fluorene by rat liver homogenate
T2 - Biochimica et Biophysica Acta - General Subjects
AU - Chen, Chiadao
AU - Lin, Chin-Chung
PY - 1969
DA - 1969/09/01
PB - Elsevier
SP - 634-640
IS - 3
VL - 184
PMID - 5821026
SN - 0006-3002
SN - 0304-4165
SN - 1872-8006
SN - 1878-2434
ER -
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BibTex (up to 50 authors)
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@article{1969_Chen,
author = {Chiadao Chen and Chin-Chung Lin},
title = {[9-14C]fluorene hydroperoxide as a possible intermediate in the hydroxylation of [9-3C]fluorene by rat liver homogenate},
journal = {Biochimica et Biophysica Acta - General Subjects},
year = {1969},
volume = {184},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/0304-4165(69)90278-5},
number = {3},
pages = {634--640},
doi = {10.1016/0304-4165(69)90278-5}
}
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MLA
Copy
Chen, Chiadao, and Chin-Chung Lin. “[9-14C]fluorene hydroperoxide as a possible intermediate in the hydroxylation of [9-3C]fluorene by rat liver homogenate.” Biochimica et Biophysica Acta - General Subjects, vol. 184, no. 3, Sep. 1969, pp. 634-640. https://doi.org/10.1016/0304-4165(69)90278-5.