,
volume 619
,
issue 1
,
pages 143-147
Rapid high-performance liquid chromatographic assay of ethynyloestradiol in rabbit plasma
Publication type: Journal Article
Publication date: 1993-09-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 03784347, 13872273
PubMed ID:
8245154
General Chemistry
Abstract
A method for the determination of ethynyloestradiol in samples of rabbit plasma containing pentobarbital and heparin, the former used as an anaesthetic and the latter as an anticoagulant, has been developed. Quantification was carried out using a reversed-phase high-performance liquid chromatographic (HPLC) method in isocratic mode at room temperature, with electrochemical detection at an applied potential of +1 V vs. Ag/AgCl. Under these conditions, the retention time for ethynyloestradiol was ca. 2.9 min, the average recovery from plasma was 74.5%, and the limit of detection was 10 pg, corresponding to a plasma concentration of 50 pg/ml using 1 ml of plasma. Natural oestrogens, oestriol, oestradiol and oestrone showed peaks that did not interfere with ethynyloestradiol, and retention times of ca. 0.8, 2.4 and 3.4 min, respectively.
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Citations from 2024:
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GOST
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Fernández N. et al. Rapid high-performance liquid chromatographic assay of ethynyloestradiol in rabbit plasma // Journal of Chromatography B Biomedical Sciences and Applications. 1993. Vol. 619. No. 1. pp. 143-147.
GOST all authors (up to 50)
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Fernández N., Dicenta F., Diez M. A., Terán M. T., Sierra M. Rapid high-performance liquid chromatographic assay of ethynyloestradiol in rabbit plasma // Journal of Chromatography B Biomedical Sciences and Applications. 1993. Vol. 619. No. 1. pp. 143-147.
Cite this
RIS
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TY - JOUR
DO - 10.1016/0378-4347(93)80458-g
UR - https://doi.org/10.1016/0378-4347(93)80458-g
TI - Rapid high-performance liquid chromatographic assay of ethynyloestradiol in rabbit plasma
T2 - Journal of Chromatography B Biomedical Sciences and Applications
AU - Fernández, Nélida
AU - Dicenta, F.
AU - Diez, María Avila
AU - Terán, M T
AU - Sierra, M.
PY - 1993
DA - 1993/09/01
PB - Elsevier
SP - 143-147
IS - 1
VL - 619
PMID - 8245154
SN - 0378-4347
SN - 1387-2273
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1993_Fernández,
author = {Nélida Fernández and F. Dicenta and María Avila Diez and M T Terán and M. Sierra},
title = {Rapid high-performance liquid chromatographic assay of ethynyloestradiol in rabbit plasma},
journal = {Journal of Chromatography B Biomedical Sciences and Applications},
year = {1993},
volume = {619},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/0378-4347(93)80458-g},
number = {1},
pages = {143--147},
doi = {10.1016/0378-4347(93)80458-g}
}
Cite this
MLA
Copy
Fernández, Nélida, et al. “Rapid high-performance liquid chromatographic assay of ethynyloestradiol in rabbit plasma.” Journal of Chromatography B Biomedical Sciences and Applications, vol. 619, no. 1, Sep. 1993, pp. 143-147. https://doi.org/10.1016/0378-4347(93)80458-g.