The chiral chromatographic separation of β-adrenoceptor blocking drugs
1
International Development Laboratories, Bristol-Myers Squibb Pharmaceutical Research Institute, Moreton, Merseyside, UK.
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Тип публикации: Journal Article
Дата публикации: 1992-06-01
scimago Q2
wos Q2
БС1
SJR: 0.628
CiteScore: 6.4
Impact factor: 3.1
ISSN: 07317085, 1873264X
PubMed ID:
1358210
Drug Discovery
Spectroscopy
Pharmaceutical Science
Clinical Biochemistry
Analytical Chemistry
Краткое описание
Over 100 chromatographic procedures for the separation of beta-blocker enantiomers are reviewed including a large number for the analysis of biological samples. All the principal chiral chromatographic procedures have found use, namely Chiral Mobile Phase Additives (CMPA), Chiral Derivatization Agents (CDA) and Chiral Stationary Phases (CSP). Chiral Mobile Phase Additives are less frequently employed than the other two procedures and many of the earlier methods were based on the use of CDAs. However, the recent development of sophisticated custom-made CSPs has allowed the separation of native (underivatized) analytes and this approach appears to be gaining in popularity. The beta-blockers are an extensive group of drugs and stereoselective separations have been reported for 40 different structures.
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Dyas A. M. The chiral chromatographic separation of β-adrenoceptor blocking drugs // Journal of Pharmaceutical and Biomedical Analysis. 1992. Vol. 10. No. 6. pp. 383-404.
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Dyas A. M. The chiral chromatographic separation of β-adrenoceptor blocking drugs // Journal of Pharmaceutical and Biomedical Analysis. 1992. Vol. 10. No. 6. pp. 383-404.
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TY - JOUR
DO - 10.1016/0731-7085(92)80057-t
UR - https://doi.org/10.1016/0731-7085(92)80057-t
TI - The chiral chromatographic separation of β-adrenoceptor blocking drugs
T2 - Journal of Pharmaceutical and Biomedical Analysis
AU - Dyas, A M
PY - 1992
DA - 1992/06/01
PB - Elsevier
SP - 383-404
IS - 6
VL - 10
PMID - 1358210
SN - 0731-7085
SN - 1873-264X
ER -
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@article{1992_Dyas,
author = {A M Dyas},
title = {The chiral chromatographic separation of β-adrenoceptor blocking drugs},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
year = {1992},
volume = {10},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/0731-7085(92)80057-t},
number = {6},
pages = {383--404},
doi = {10.1016/0731-7085(92)80057-t}
}
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MLA
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Dyas, A. M.. “The chiral chromatographic separation of β-adrenoceptor blocking drugs.” Journal of Pharmaceutical and Biomedical Analysis, vol. 10, no. 6, Jun. 1992, pp. 383-404. https://doi.org/10.1016/0731-7085(92)80057-t.