Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: application to N,N-dimethylformamide.
Тип публикации: Journal Article
Дата публикации: 1993-08-01
scimago Q2
wos Q2
white level БС1
SJR: 0.628
CiteScore: 6.4
Impact factor: 3.1
ISSN: 07317085, 1873264X
PubMed ID:
8257732
Drug Discovery
Spectroscopy
Pharmaceutical Science
Clinical Biochemistry
Analytical Chemistry
Краткое описание
The metabolism of N,N-dimethylformamide in the Sprague-Dawley rat has been reinvestigated using NMR spectroscopy of urine. In particular, through the use of N,N-dimethylformamide-d7 (DMF-d7) and 2H-NMR spectroscopy, the principal metabolites of this compound have been confirmed in a direct manner. The use of inverse-detected two-dimensional 2H-13C correlation with 13C decoupling aided metabolite identification through the provision of 13C chemical shifts.
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ГОСТ
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Farrant R. et al. Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: application to N,N-dimethylformamide. // Journal of Pharmaceutical and Biomedical Analysis. 1993. Vol. 11. No. 8. pp. 687-692.
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Farrant R., Salman S. R., Lindon J., Cupid B. C., Nicholson J. K. Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: application to N,N-dimethylformamide. // Journal of Pharmaceutical and Biomedical Analysis. 1993. Vol. 11. No. 8. pp. 687-692.
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RIS
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TY - JOUR
DO - 10.1016/0731-7085(93)80175-Z
UR - https://doi.org/10.1016/0731-7085(93)80175-Z
TI - Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: application to N,N-dimethylformamide.
T2 - Journal of Pharmaceutical and Biomedical Analysis
AU - Farrant, R.Duncan
AU - Salman, Salman R.
AU - Lindon, John
AU - Cupid, Belinda C
AU - Nicholson, Jeremy K
PY - 1993
DA - 1993/08/01
PB - Elsevier
SP - 687-692
IS - 8
VL - 11
PMID - 8257732
SN - 0731-7085
SN - 1873-264X
ER -
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BibTex (до 50 авторов)
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@article{1993_Farrant,
author = {R.Duncan Farrant and Salman R. Salman and John Lindon and Belinda C Cupid and Jeremy K Nicholson},
title = {Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: application to N,N-dimethylformamide.},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
year = {1993},
volume = {11},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/0731-7085(93)80175-Z},
number = {8},
pages = {687--692},
doi = {10.1016/0731-7085(93)80175-Z}
}
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MLA
Скопировать
Farrant, R.Duncan, et al. “Deuterium NMR spectroscopy of biofluids for the identification of drug metabolites: application to N,N-dimethylformamide..” Journal of Pharmaceutical and Biomedical Analysis, vol. 11, no. 8, Aug. 1993, pp. 687-692. https://doi.org/10.1016/0731-7085(93)80175-Z.
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