The methyl-5α-dihydrotestosterones mesterolone and drostanolone; gas chromatographic/mass spectrometric characterization of the urinary metabolites
1
Netherlands Institute for Drugs and Doping Research, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
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Publication type: Journal Article
Publication date: 1992-05-01
scimago Q2
wos Q3
SJR: 0.729
CiteScore: 6.0
Impact factor: 2.5
ISSN: 09600760, 18791220
PubMed ID:
1606052
Biochemistry
Molecular Biology
Cell Biology
Clinical Biochemistry
Molecular Medicine
Endocrinology
Endocrinology, Diabetes and Metabolism
Abstract
Before including the detection of the methyl-5 alpha-dihydrotestosterones mesterolone (1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one) and drostanolone (2 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one) in doping control procedures, their urinary metabolites were characterized by gas chromatography/mass spectrometry. Several metabolites were found after enzymatic hydrolysis and conversion of the respective metabolites to their trimethylsilyl-enol-trimethylsilyl ether derivatives. The major metabolites of mesterolone and drostanolone were identified as 1 alpha-methyl-androsterone and 2 alpha-methyl-androsterone, respectively. The parent compounds and the intermediate 3 alpha,17 beta-dihydroxysteroid metabolites were detected as well. The reduction into the corresponding 3 beta-hydroxysteroids was a minor metabolic pathway. All metabolites were found to be conjugated to glucuronic acid.
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GOST
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de Boer D. et al. The methyl-5α-dihydrotestosterones mesterolone and drostanolone; gas chromatographic/mass spectrometric characterization of the urinary metabolites // Journal of Steroid Biochemistry and Molecular Biology. 1992. Vol. 42. No. 3-4. pp. 411-419.
GOST all authors (up to 50)
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de Boer D., de Jong E., Maes R. A., van Rossum J. The methyl-5α-dihydrotestosterones mesterolone and drostanolone; gas chromatographic/mass spectrometric characterization of the urinary metabolites // Journal of Steroid Biochemistry and Molecular Biology. 1992. Vol. 42. No. 3-4. pp. 411-419.
Cite this
RIS
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TY - JOUR
DO - 10.1016/0960-0760(92)90146-a
UR - https://doi.org/10.1016/0960-0760(92)90146-a
TI - The methyl-5α-dihydrotestosterones mesterolone and drostanolone; gas chromatographic/mass spectrometric characterization of the urinary metabolites
T2 - Journal of Steroid Biochemistry and Molecular Biology
AU - de Boer, D
AU - de Jong, EC
AU - Maes, R. A.A.
AU - van Rossum, J.M.
PY - 1992
DA - 1992/05/01
PB - Elsevier
SP - 411-419
IS - 3-4
VL - 42
PMID - 1606052
SN - 0960-0760
SN - 1879-1220
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1992_de Boer,
author = {D de Boer and EC de Jong and R. A.A. Maes and J.M. van Rossum},
title = {The methyl-5α-dihydrotestosterones mesterolone and drostanolone; gas chromatographic/mass spectrometric characterization of the urinary metabolites},
journal = {Journal of Steroid Biochemistry and Molecular Biology},
year = {1992},
volume = {42},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/0960-0760(92)90146-a},
number = {3-4},
pages = {411--419},
doi = {10.1016/0960-0760(92)90146-a}
}
Cite this
MLA
Copy
de Boer, D., et al. “The methyl-5α-dihydrotestosterones mesterolone and drostanolone; gas chromatographic/mass spectrometric characterization of the urinary metabolites.” Journal of Steroid Biochemistry and Molecular Biology, vol. 42, no. 3-4, May. 1992, pp. 411-419. https://doi.org/10.1016/0960-0760(92)90146-a.