Synthesis of 4′-fluoroadenosine as an inhibitor of S-adenosyl-L-homocysteine hydrolase
1
Laboratoire de Chimie Bioorganique, URA 459, UFR Sciences de Reims BP 347, 51062 REIMS Cédex, FRANCE
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Publication type: Journal Article
Publication date: 1995-07-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Synthesis of 4′-Fluoroadenosine was achieved via N 6 -benzoyl-9-(5-deoxy-2, 3-0-dibenzoyl-β-D-erythro-pent-4-enofuranosyl)adenine as intermediate. Evaluation of its inhibitory effect on S-adenosyl-L-homocysteine hydrolase exhibited interesting properties. 4′-Fluoroadenosine caused a time-dependent inactivation of the enzyme, this inactivation was accompanied by reduction of the enzyme-bound NAD + (E.NAD + ) to NADH.
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Total citations:
21
Citations from 2025:
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(4.76%)
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MLA
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GOST
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Guillerm D. et al. Synthesis of 4′-fluoroadenosine as an inhibitor of S-adenosyl-L-homocysteine hydrolase // Bioorganic and Medicinal Chemistry Letters. 1995. Vol. 5. No. 14. pp. 1455-1460.
GOST all authors (up to 50)
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Guillerm D., Muzard M., ALLART B., Guillerm G. Synthesis of 4′-fluoroadenosine as an inhibitor of S-adenosyl-L-homocysteine hydrolase // Bioorganic and Medicinal Chemistry Letters. 1995. Vol. 5. No. 14. pp. 1455-1460.
Cite this
RIS
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TY - JOUR
DO - 10.1016/0960-894X(95)00256-S
UR - https://doi.org/10.1016/0960-894X(95)00256-S
TI - Synthesis of 4′-fluoroadenosine as an inhibitor of S-adenosyl-L-homocysteine hydrolase
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Guillerm, D
AU - Muzard, M
AU - ALLART, B.
AU - Guillerm, G.
PY - 1995
DA - 1995/07/01
PB - Elsevier
SP - 1455-1460
IS - 14
VL - 5
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1995_Guillerm,
author = {D Guillerm and M Muzard and B. ALLART and G. Guillerm},
title = {Synthesis of 4′-fluoroadenosine as an inhibitor of S-adenosyl-L-homocysteine hydrolase},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {1995},
volume = {5},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/0960-894X(95)00256-S},
number = {14},
pages = {1455--1460},
doi = {10.1016/0960-894X(95)00256-S}
}
Cite this
MLA
Copy
Guillerm, D., et al. “Synthesis of 4′-fluoroadenosine as an inhibitor of S-adenosyl-L-homocysteine hydrolase.” Bioorganic and Medicinal Chemistry Letters, vol. 5, no. 14, Jul. 1995, pp. 1455-1460. https://doi.org/10.1016/0960-894X(95)00256-S.