Open Access
Open access
Elsevier
Life Sciences
,  volume 69 ,  issue 2 ,  pages 229-237

Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes

KYONG NYON NAM 1
, 
Young Joon Jo 2
, 
Young A. Kim 2
, 
Jin Hai Hyun 3
, 
Ha Young Kim 1
1
 
Department of Life Science, University of Seoul, Seoul 130-743, South Korea. | 
2
 
3
 
Publication type: Journal Article
Publication date: 2001-06-01
Elsevier
scimago Q1
wos Q1
SJR: 1.315
CiteScore: 10.9
Impact factor: 5.1
ISSN: 00243205, 18790631
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Paecilomyces tenuipes is one of the famous Chinese medicinal entomopathogenic fungi that parasites in the lavae of silkworm. Two cytotoxic components were isolated from methanolic extract of the carpophores of this fungus that was cultivated artificially. Spectral analyses of the cytotoxic components showed that they were known ergosterol peroxide (5alpha,8alpha-epidioxy-24(R)-methylcholesta-6,22-dien-3beta-ol) and acetoxyscirpenediol (4beta-acetoxyscirpene-3alpha,15-diol) that were isolated for the first time from this fungus. The 50% inhibitory concentrations (IC50) of ergosterol peroxide against human gastric tumor cell line (SNU-1), human hepatoma cell line (SNU-354), human colorectal tumor cell line (SNU-C4) and murine sarcoma-180 were 18.7, 158.2, 84.6 and 74.1 microM, respectively. The IC50 values of acetoxyscirpenediol against SNU-1, SNU-C4, SNU-354 and sarcoma-180 were 1.2,4.0, 2.2 and 1.9 microM, respectively. Cytotoxic activities of acetoxyscirpenediol were about 4.0-6.6 times stronger than those of cisplatin which is currently used clinically for cancer patients.
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GOST |
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GOST Copy
NAM K. N. et al. Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes // Life Sciences. 2001. Vol. 69. No. 2. pp. 229-237.
GOST all authors (up to 50) Copy
NAM K. N., Jo Y. J., Kim Y. A., Hai Hyun J., Kim H. Y. Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes // Life Sciences. 2001. Vol. 69. No. 2. pp. 229-237.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/S0024-3205(01)01125-0
UR - https://doi.org/10.1016/S0024-3205(01)01125-0
TI - Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes
T2 - Life Sciences
AU - NAM, KYONG NYON
AU - Jo, Young Joon
AU - Kim, Young A.
AU - Hai Hyun, Jin
AU - Kim, Ha Young
PY - 2001
DA - 2001/06/01
PB - Elsevier
SP - 229-237
IS - 2
VL - 69
PMID - 11441913
SN - 0024-3205
SN - 1879-0631
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2001_NAM,
author = {KYONG NYON NAM and Young Joon Jo and Young A. Kim and Jin Hai Hyun and Ha Young Kim},
title = {Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes},
journal = {Life Sciences},
year = {2001},
volume = {69},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/S0024-3205(01)01125-0},
number = {2},
pages = {229--237},
doi = {10.1016/S0024-3205(01)01125-0}
}
MLA
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MLA Copy
NAM, KYONG NYON, et al. “Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes.” Life Sciences, vol. 69, no. 2, Jun. 2001, pp. 229-237. https://doi.org/10.1016/S0024-3205(01)01125-0.