Open Access
Schizophrenia
Publication type: Journal Article
Publication date: 2016-07-01
scimago Q1
wos Q1
SJR: 12.113
CiteScore: 87.6
Impact factor: 88.5
ISSN: 01406736, 1474547X
PubMed ID:
26777917
General Medicine
Abstract
Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement of other brain areas and circuits. Disturbances of synaptic function might underlie abnormalities of neuronal connectivity that possibly involves interneurons, but the precise nature, location, and timing of these events are uncertain. At present, treatment mainly consists of antipsychotic drugs combined with psychological therapies, social support, and rehabilitation, but a pressing need for more effective treatments and delivery of services exists. Advances in genomics, epidemiology, and neuroscience have led to great progress in understanding the disorder, and the opportunities for further scientific breakthrough are numerous--but so are the challenges.
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Metrics
1.5k
Total citations:
1538
Citations from 2024:
354
(23.03%)
Cite this
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BibTex |
MLA
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/S0140-6736(15)01121-6
UR - https://doi.org/10.1016/S0140-6736(15)01121-6
TI - Schizophrenia
T2 - The Lancet
AU - Donne, Scott
AU - Sawa, Akira
AU - Mortensen, Poul E.
PY - 2016
DA - 2016/07/01
PB - Elsevier
SP - 86-97
IS - 10039
VL - 388
PMID - 26777917
SN - 0140-6736
SN - 1474-547X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Donne,
author = {Scott Donne and Akira Sawa and Poul E. Mortensen},
title = {Schizophrenia},
journal = {The Lancet},
year = {2016},
volume = {388},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/S0140-6736(15)01121-6},
number = {10039},
pages = {86--97},
doi = {10.1016/S0140-6736(15)01121-6}
}
Cite this
MLA
Copy
Donne, Scott, et al. “Schizophrenia.” The Lancet, vol. 388, no. 10039, Jul. 2016, pp. 86-97. https://doi.org/10.1016/S0140-6736(15)01121-6.