DNA binding properties of the marine sponge pigment fascaplysin.
1
Solvias AG, Basel, Switzerland.
|
2
Oncology Research, Novartis Pharma AG, CH-4002 Basel, Switzerland
|
Publication type: Journal Article
Publication date: 2001-04-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
11354674
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Association of fascaplysin with double-stranded calf thymus DNA was investigated by means of isothermal titration calorimetry, absorption spectroscopy, and circular dichroism. The UV spectroscopic data could be well interpreted in terms of a two-site model for the binding of fascaplysin to DNA revealing affinity constants of K1 = 2.5 x 10(6) M(-1) and K2 = 7.5 x 10(4) M(-1) (base pairs of DNA). Based on the typical change observed in the absorption and circular dichroism spectra, intercalation of fascaplysin is regarded as the major binding mode. The calorimetric titration curves showed an exothermic reaction which was exhausted at a 2:1 base pair/drug; ratio. This finding is in agreement with an intercalation model comprising nearest neighbor exclusion. In addition, significantly weaker non-intercalative DNA interactions can be observed at high drug concentration. By comparison of all these data with the binding behavior of known intercalating agents, it is concluded that fascaplysin intercalates into DNA.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
2
4
6
8
10
|
|
|
Tetrahedron Letters
10 publications, 14.08%
|
|
|
Marine Drugs
10 publications, 14.08%
|
|
|
Bioorganic and Medicinal Chemistry
5 publications, 7.04%
|
|
|
Molecules
3 publications, 4.23%
|
|
|
European Journal of Medicinal Chemistry
3 publications, 4.23%
|
|
|
Bioorganic and Medicinal Chemistry Letters
3 publications, 4.23%
|
|
|
Organic and Biomolecular Chemistry
3 publications, 4.23%
|
|
|
Chemical Communications
2 publications, 2.82%
|
|
|
RSC Advances
2 publications, 2.82%
|
|
|
Bulletin of Experimental Biology and Medicine
1 publication, 1.41%
|
|
|
Recent Patents on Anti-Cancer Drug Discovery
1 publication, 1.41%
|
|
|
European Journal of Cancer
1 publication, 1.41%
|
|
|
International Journal of Oncology
1 publication, 1.41%
|
|
|
Investigational New Drugs
1 publication, 1.41%
|
|
|
Chinese Journal of Oceanology and Limnology
1 publication, 1.41%
|
|
|
Cell Death and Disease
1 publication, 1.41%
|
|
|
European Journal of Pharmaceutical Sciences
1 publication, 1.41%
|
|
|
Journal of Pharmaceutical and Biomedical Analysis
1 publication, 1.41%
|
|
|
Chemistry & Biology
1 publication, 1.41%
|
|
|
Tetrahedron
1 publication, 1.41%
|
|
|
Gene
1 publication, 1.41%
|
|
|
Bioorganic Chemistry
1 publication, 1.41%
|
|
|
Thermochimica Acta
1 publication, 1.41%
|
|
|
ChemistrySelect
1 publication, 1.41%
|
|
|
Journal of Natural Products
1 publication, 1.41%
|
|
|
ACS Combinatorial Science
1 publication, 1.41%
|
|
|
Chemical Reviews
1 publication, 1.41%
|
|
|
Journal of Medicinal Chemistry
1 publication, 1.41%
|
|
|
Journal of Organic Chemistry
1 publication, 1.41%
|
|
|
2
4
6
8
10
|
Publishers
|
5
10
15
20
25
30
|
|
|
Elsevier
30 publications, 42.25%
|
|
|
MDPI
13 publications, 18.31%
|
|
|
Royal Society of Chemistry (RSC)
9 publications, 12.68%
|
|
|
Springer Nature
5 publications, 7.04%
|
|
|
American Chemical Society (ACS)
5 publications, 7.04%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 1.41%
|
|
|
Spandidos Publications
1 publication, 1.41%
|
|
|
Wiley
1 publication, 1.41%
|
|
|
Institute of Molecular Biology and Genetics (NAS Ukraine)
1 publication, 1.41%
|
|
|
Oxford University Press
1 publication, 1.41%
|
|
|
Proceedings of the National Academy of Sciences (PNAS)
1 publication, 1.41%
|
|
|
Taylor & Francis
1 publication, 1.41%
|
|
|
Research Square Platform LLC
1 publication, 1.41%
|
|
|
5
10
15
20
25
30
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
71
Total citations:
71
Citations from 2024:
6
(8.45%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Hörmann A., Chaudhuri B., Fretz H. DNA binding properties of the marine sponge pigment fascaplysin. // Bioorganic and Medicinal Chemistry. 2001. Vol. 9. No. 4. pp. 917-921.
GOST all authors (up to 50)
Copy
Hörmann A., Chaudhuri B., Fretz H. DNA binding properties of the marine sponge pigment fascaplysin. // Bioorganic and Medicinal Chemistry. 2001. Vol. 9. No. 4. pp. 917-921.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/S0968-0896(00)00313-8
UR - https://doi.org/10.1016/S0968-0896(00)00313-8
TI - DNA binding properties of the marine sponge pigment fascaplysin.
T2 - Bioorganic and Medicinal Chemistry
AU - Hörmann, Aldo
AU - Chaudhuri, Bhabatosh
AU - Fretz, Heinz
PY - 2001
DA - 2001/04/01
PB - Elsevier
SP - 917-921
IS - 4
VL - 9
PMID - 11354674
SN - 0968-0896
SN - 1464-3391
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2001_Hörmann,
author = {Aldo Hörmann and Bhabatosh Chaudhuri and Heinz Fretz},
title = {DNA binding properties of the marine sponge pigment fascaplysin.},
journal = {Bioorganic and Medicinal Chemistry},
year = {2001},
volume = {9},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/S0968-0896(00)00313-8},
number = {4},
pages = {917--921},
doi = {10.1016/S0968-0896(00)00313-8}
}
Cite this
MLA
Copy
Hörmann, Aldo, et al. “DNA binding properties of the marine sponge pigment fascaplysin..” Bioorganic and Medicinal Chemistry, vol. 9, no. 4, Apr. 2001, pp. 917-921. https://doi.org/10.1016/S0968-0896(00)00313-8.