Bioactive rare earth-based inorganic-organic hybrid biomaterials for wound healing and repair

• This review describes the structure of rear-earth-based hybrid biomaterials (REH); • This review describes the biological properties of REH; • This review describes the wound healing applications of REH; • This review describes the prospective of REH in future wound healing; Rare earth-based biomaterials have representative optical/magnetic properties, which have shown the great potential in biomedical applications. In recent years, many studies have shown that rare earth-based biomaterials also possess the special biological properties, including antioxidation, antiinflammation and antibacterial activity, which also enabled their potential applications in enhancing wound healing and skin tissue regeneration. Thus, rare earth-based inorganic-organic hybrid biomaterials (REH) with special biological activities have been developed for wound healing and skin regeneration. REH biomaterials possess the double advantages of inorganic rare earth and organic biomedical polymers, and demonstrate the promising applications in wound healing and repair. In this work, we thoroughly reviewed the recent advances and findings on the fabrication and wound repair applications of bioactive REH biomaterials. The personal insights regarding as the challenges and perspectives on rare-earth nanocomposites in wound repair were also presented. Graphical Abstract .