Biochimica et Biophysica Acta - Molecular Basis of Disease, volume 1862, issue 4, pages 733-740

Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve

Kostina A.A. ^{1, 2}

Uspensky Vladimir Е ³

Irtyuga O. ^{1, 4}

Ignatieva Elena V ³

Freylikhman O. ³

Gavriliuk Natalia D ³

Moiseeva O. ³

Zhuk Sergey ³

Tomilin Alexey N. ⁵

Kostareva Аnna А ^{1, 4}

Malashicheva Anna В. ^{6, 7}

Hide authors affiliations Show authors affiliations: 7 affiliations

Almazov Federal Medical Research Centre, Saint-Petersburg, Russia |

University of Verona, verona, Italy. |

Almazov Federal Medical Research Centre, Saint-Petersburg, Russia. |

⁴

ITMO University, Institute of translational Medicine, St. Petersburg, Russia. |

⁵

Institute of Cytology, Russian Academy of Sciences, Saint-Petersburg, Russia |

⁶

Almazov Medical Research Centre, St. Petersburg State University, Saint-Petersburg, Russia

Saint Petersburg State University

Almazov National Medical Research Centre

⁷

ITMO University, Institute of Translational Medicine, St. Petersburg, Russia |

Publication type: Journal Article

Publication date: 2016-04-01

Elsevier

Journal: Biochimica et Biophysica Acta - Molecular Basis of Disease

Quartile SCImago

Quartile WOS

Impact factor: 6.2

ISSN: 09254439

DOI: 10.1016/j.bbadis.2016.02.006

Copy DOI

Molecular Biology

Molecular Medicine

Abstract

Bicuspid aortic valve is the most common congenital heart malformation and the reasons for the aortopathies associated with bicuspid aortic valve remain unclear. NOTCH1 mutations are associated with bicuspid aortic valve and have been found in individuals with various left ventricular outflow tract abnormalities. Notch is a key signaling during cardiac valve formation that promotes the endothelial-to-mesenchymal transition. We address the role of Notch signaling in human aortic endothelial cells from patients with bicuspid aortic valve and aortic aneurysm. Aortic endothelial cells were isolated from tissue fragments of bicuspid aortic valve-associated thoracic aortic aneurysm patients and from healthy donors. Endothelial-to-mesenchymal transition was induced by activation of Notch signaling. Effectiveness of the transition was estimated by loss of endothelial and gain of mesenchymal markers by immunocytochemistry and qPCR. We show that aortic endothelial cells from the patients with aortic aneurysm and bicuspid aortic valve have down regulated Notch signaling and fail to activate Notch-dependent endothelial-to-mesenchymal transition in response to its stimulation by different Notch ligands. Our findings support the idea that bicuspid aortic valve and associated aortic aneurysm is associated with dysregulation of the entire Notch signaling pathway independently on the specific gene mutation. • Patients with bicuspid aortic valve and dilated aortas have attenuated Notch signaling • Endothelial cells derived from aortas of BAV/AoA patients have impaired Notch-dependent EMT induction • Notch pathway defect in BAV-associated aortic aneurysm is not obligatory associated with mutation in NOTCH1

By date By citations

Citations by journals

	1 2 3 4 5
Frontiers in Physiology	Frontiers in Physiology, 5, 8.62% Frontiers in Physiology 5 publications, 8.62%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 6.9% International Journal of Molecular Sciences 4 publications, 6.9%
Journal of Molecular and Cellular Cardiology	Journal of Molecular and Cellular Cardiology, 2, 3.45% Journal of Molecular and Cellular Cardiology 2 publications, 3.45%
Cardiovascular Research	Cardiovascular Research, 2, 3.45% Cardiovascular Research 2 publications, 3.45%
Complex Issues of Cardiovascular Diseases	Complex Issues of Cardiovascular Diseases, 2, 3.45% Complex Issues of Cardiovascular Diseases 2 publications, 3.45%
Cell and Tissue Biology	Cell and Tissue Biology, 1, 1.72% Cell and Tissue Biology 1 publication, 1.72%
Current Cardiology Reviews	Current Cardiology Reviews, 1, 1.72% Current Cardiology Reviews 1 publication, 1.72%
Biochemistry and Cell Biology	Biochemistry and Cell Biology, 1, 1.72% Biochemistry and Cell Biology 1 publication, 1.72%
DNA and Cell Biology	DNA and Cell Biology, 1, 1.72% DNA and Cell Biology 1 publication, 1.72%
International Journal of Oncology	International Journal of Oncology, 1, 1.72% International Journal of Oncology 1 publication, 1.72%
Journal of the American Heart Association	Journal of the American Heart Association, 1, 1.72% Journal of the American Heart Association 1 publication, 1.72%
Arteriosclerosis, Thrombosis, and Vascular Biology	Arteriosclerosis, Thrombosis, and Vascular Biology, 1, 1.72% Arteriosclerosis, Thrombosis, and Vascular Biology 1 publication, 1.72%
Cell Transplantation	Cell Transplantation, 1, 1.72% Cell Transplantation 1 publication, 1.72%
Asian Cardiovascular and Thoracic Annals	Asian Cardiovascular and Thoracic Annals, 1, 1.72% Asian Cardiovascular and Thoracic Annals 1 publication, 1.72%
Cells	Cells, 1, 1.72% Cells 1 publication, 1.72%
Biomedicines	Biomedicines, 1, 1.72% Biomedicines 1 publication, 1.72%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 1, 1.72% Frontiers in Cell and Developmental Biology 1 publication, 1.72%
Journal of Imaging	Journal of Imaging, 1, 1.72% Journal of Imaging 1 publication, 1.72%
Nature Communications	Nature Communications, 1, 1.72% Nature Communications 1 publication, 1.72%
Journal of Translational Medicine	Journal of Translational Medicine, 1, 1.72% Journal of Translational Medicine 1 publication, 1.72%
Heart and Vessels	Heart and Vessels, 1, 1.72% Heart and Vessels 1 publication, 1.72%
Cell and Tissue Research	Cell and Tissue Research, 1, 1.72% Cell and Tissue Research 1 publication, 1.72%
Pediatric Research	Pediatric Research, 1, 1.72% Pediatric Research 1 publication, 1.72%
BMC Medical Genetics	BMC Medical Genetics, 1, 1.72% BMC Medical Genetics 1 publication, 1.72%
Scientific Reports	Scientific Reports, 1, 1.72% Scientific Reports 1 publication, 1.72%
Nature Genetics	Nature Genetics, 1, 1.72% Nature Genetics 1 publication, 1.72%
Trends in Cardiovascular Medicine	Trends in Cardiovascular Medicine, 1, 1.72% Trends in Cardiovascular Medicine 1 publication, 1.72%
Biochemical and Biophysical Research Communications	Biochemical and Biophysical Research Communications, 1, 1.72% Biochemical and Biophysical Research Communications 1 publication, 1.72%
Clinica Chimica Acta	Clinica Chimica Acta, 1, 1.72% Clinica Chimica Acta 1 publication, 1.72%
	1 2 3 4 5

Citations by publishers

	2 4 6 8 10 12 14
Elsevier	Elsevier, 14, 24.14% Elsevier 14 publications, 24.14%
Springer Nature	Springer Nature, 8, 13.79% Springer Nature 8 publications, 13.79%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 7, 12.07% Multidisciplinary Digital Publishing Institute (MDPI) 7 publications, 12.07%
Frontiers Media S.A.	Frontiers Media S.A., 6, 10.34% Frontiers Media S.A. 6 publications, 10.34%
Oxford University Press	Oxford University Press, 4, 6.9% Oxford University Press 4 publications, 6.9%
Wiley	Wiley, 3, 5.17% Wiley 3 publications, 5.17%
SAGE	SAGE, 2, 3.45% SAGE 2 publications, 3.45%
NII KPSSZ	NII KPSSZ, 2, 3.45% NII KPSSZ 2 publications, 3.45%
Pleiades Publishing	Pleiades Publishing, 1, 1.72% Pleiades Publishing 1 publication, 1.72%
Bentham Science	Bentham Science, 1, 1.72% Bentham Science 1 publication, 1.72%
Canadian Science Publishing	Canadian Science Publishing, 1, 1.72% Canadian Science Publishing 1 publication, 1.72%
Mary Ann Liebert	Mary Ann Liebert, 1, 1.72% Mary Ann Liebert 1 publication, 1.72%
Spandidos Publications	Spandidos Publications, 1, 1.72% Spandidos Publications 1 publication, 1.72%
Wolters Kluwer Health	Wolters Kluwer Health, 1, 1.72% Wolters Kluwer Health 1 publication, 1.72%
Taylor & Francis	Taylor & Francis, 1, 1.72% Taylor & Francis 1 publication, 1.72%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 1.72% American Association for Cancer Research (AACR) 1 publication, 1.72%
Russian Society of Cardiology	Russian Society of Cardiology, 1, 1.72% Russian Society of Cardiology 1 publication, 1.72%
Almazov National Medical Research Centre	Almazov National Medical Research Centre, 1, 1.72% Almazov National Medical Research Centre 1 publication, 1.72%
	2 4 6 8 10 12 14

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","",""],"datasets":[{"label":"Citations number","data":[1,11,9,9,9,6,7,5,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["1.72","18.97","15.52","15.52","15.52","10.34","12.07","8.62","1.72"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Frontiers in Physiology","International Journal of Molecular Sciences","Journal of Molecular and Cellular Cardiology","Cardiovascular Research","Complex Issues of Cardiovascular Diseases","Cell and Tissue Biology","Current Cardiology Reviews","Biochemistry and Cell Biology","DNA and Cell Biology","International Journal of Oncology","Journal of the American Heart Association","Arteriosclerosis, Thrombosis, and Vascular Biology","Cell Transplantation","Asian Cardiovascular and Thoracic Annals","Cells","Biomedicines","Frontiers in Cell and Developmental Biology","Journal of Imaging","Nature Communications","Journal of Translational Medicine","Heart and Vessels","Cell and Tissue Research","Pediatric Research","BMC Medical Genetics","Scientific Reports","Nature Genetics","Trends in Cardiovascular Medicine","Biochemical and Biophysical Research Communications","Clinica Chimica Acta"],"ids":[15670,14627,5720,9200,28311,16847,22843,16014,755,18049,4124,20867,24323,9716,25293,24421,12128,17161,3231,18128,1889,21253,14842,11173,13767,5840,5563,12390,4828],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/7jslgtSskvH8CUAnSh2E6iJdntwdkN3SWquec7Ma_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/qZfu8vVyaDIo81Au73p6SNE8AGGzf73yfiTC33bu_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/ruydfaB80LDjlkYqsfOeUAZohOIODyq7bQzis5O7_medium.webp","\/storage\/images\/resized\/ruydfaB80LDjlkYqsfOeUAZohOIODyq7bQzis5O7_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[5,4,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[8.62,6.9,3.45,3.45,3.45,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Springer Nature","Multidisciplinary Digital Publishing Institute (MDPI)","Frontiers Media S.A.","Oxford University Press","Wiley","SAGE","NII KPSSZ","Pleiades Publishing","Bentham Science","Canadian Science Publishing","Mary Ann Liebert","Spandidos Publications","Wolters Kluwer Health","Taylor & Francis","American Association for Cancer Research (AACR)","Russian Society of Cardiology","Almazov National Medical Research Centre"],"ids":[17,8,202,208,19,11,31,7528,101,39,6942,230,1097,32,18,2286,4861,7429],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/ruydfaB80LDjlkYqsfOeUAZohOIODyq7bQzis5O7_medium.webp","\/storage\/images\/resized\/7jslgtSskvH8CUAnSh2E6iJdntwdkN3SWquec7Ma_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/qZfu8vVyaDIo81Au73p6SNE8AGGzf73yfiTC33bu_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/cfuVw6XIq2mATDNJdXiose3W8qYbkmaVSpHoP8XL_medium.webp","\/storage\/images\/resized\/GXJGGkZ0XWj92TiOedUJzgYiWDqP2CdUEDiDaivi_medium.webp","\/storage\/images\/resized\/r4dPIiwE4NOnNpNFb2hlNPFxeRmhgl7h6wJGTtKg_medium.webp"],"datasets":[{"label":"","data":[14,8,7,6,4,3,2,2,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[24.14,13.79,12.07,10.34,6.9,5.17,3.45,3.45,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72,1.72],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Metrics

Cite this

GOST |

Cite this

GOST Copy

Kostina A. et al. Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve // Biochimica et Biophysica Acta - Molecular Basis of Disease. 2016. Vol. 1862. No. 4. pp. 733-740.

GOST all authors (up to 50) Copy

Kostina A., Uspensky V. Е., Irtyuga O., Ignatieva E. V., Freylikhman O., Gavriliuk N. D., Moiseeva O., Zhuk S., Tomilin A. N., Kostareva А. А., Malashicheva A. В. Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve // Biochimica et Biophysica Acta - Molecular Basis of Disease. 2016. Vol. 1862. No. 4. pp. 733-740.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.bbadis.2016.02.006

UR - https://doi.org/10.1016%2Fj.bbadis.2016.02.006

TI - Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve

T2 - Biochimica et Biophysica Acta - Molecular Basis of Disease

AU - Kostina, A.A.

AU - Uspensky, Vladimir Е

AU - Irtyuga, O.

AU - Ignatieva, Elena V

AU - Freylikhman, O.

AU - Gavriliuk, Natalia D

AU - Moiseeva, O.

AU - Zhuk, Sergey

AU - Tomilin, Alexey N.

AU - Kostareva, Аnna А

AU - Malashicheva, Anna В.

PY - 2016

DA - 2016/04/01 00:00:00

PB - Elsevier

SP - 733-740

IS - 4

VL - 1862

SN - 0925-4439

ER -

BibTex |

Cite this

BibTex Copy

@article{2016_Kostina,

author = {A.A. Kostina and Vladimir Е Uspensky and O. Irtyuga and Elena V Ignatieva and O. Freylikhman and Natalia D Gavriliuk and O. Moiseeva and Sergey Zhuk and Alexey N. Tomilin and Аnna А Kostareva and Anna В. Malashicheva},

title = {Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve},

journal = {Biochimica et Biophysica Acta - Molecular Basis of Disease},

year = {2016},

volume = {1862},

publisher = {Elsevier},

month = {apr},

url = {https://doi.org/10.1016%2Fj.bbadis.2016.02.006},

number = {4},

pages = {733--740},

doi = {10.1016/j.bbadis.2016.02.006}

}

MLA

Cite this

MLA Copy

Kostina, A.A., et al. “Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve.” Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1862, no. 4, Apr. 2016, pp. 733-740. https://doi.org/10.1016%2Fj.bbadis.2016.02.006.

Found error?

Publisher

Elsevier

Journal

Biochimica et Biophysica Acta - Molecular Basis of Disease

Quartile SCImago

Quartile WOS

Impact factor

6.2

ISSN

09254439 (Print)

Labs

Laboratory of Regenerative Biomedicine

Profiles

Malashicheva, Anna B