Laboratory of Regenerative Biomedicine

The main area of research is related to the study of molecular links controlling osteogenic differentiation of mesenchymal stem cells (MSCs) of various origins – heart, bone, tooth. Osteogenic differentiation is a multi-stage process that proceeds in a similar way normally in the development of bone tissue, as well as in pathologies such as, for example, calcification of blood vessels and heart valves. It is obvious that one of the key roles in osteogenic differentiation is played by the interactions of the endothelium and the underlying cells, usually of mesenchymal origin. One of the areas of research is related to the search for specific molecular characteristics of endothelial cells, depending on which the endothelium is able to induce and enhance or suppress osteogenic differentiation of mesenchymal stem cells with the ultimate goal of creating approaches for obtaining endothelial cells with specified osteoinductive/osteoprotective properties. Another area of research in the laboratory is the multi-sided characterization of the Notch signaling pathway. Notch is a highly conserved signaling pathway that regulates the development and differentiation of many types of tissues and affects basic cellular processes such as cell proliferation, differentiation and apoptosis. Using a variety of cellular models and molecular genetic methods, we study the effect of Notch activation and inactivation on cellular differentiation. The work is carried out both on the basis of the Institute of Cytology and in close cooperation with several domestic and foreign partners.