Biochimica et Biophysica Acta - Molecular Basis of Disease, volume 1866, issue 3, pages 165631
Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states
Malashicheva Anna В.
1, 2
,
Kostina A.A.
3, 4
,
Kostareva Anna
5
,
Irtyuga O.
5
,
Gordeev Mikhail
5
,
Uspensky Vladimir
5
1
Publication type: Journal Article
Publication date: 2020-03-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.2
ISSN: 09254439
Molecular Biology
Molecular Medicine
Abstract
Aneurysms of the thoracic aorta are a “silent killer” with no evident clinical signs until the fatal outcome. Molecular and genetic bases of thoracic aortic aneurysms mainly include transforming growth factor beta signaling, smooth muscle contractile units and metabolism genes, and extracellular matrix genes. In recent studies, a role of Notch signaling, among other pathways, has emerged in disease pathogenesis. Notch is a highly conserved signaling pathway that regulates the development and differentiation of many types of tissues and influences major cellular processes such as cell proliferation, differentiation and apoptosis. Mutations in several Notch signaling components have been associated with a number of heart defects, demonstrating an essential role of Notch signaling both in cardiovascular system development and its maintenance during postnatal life. This review discusses the role of Notch signaling in the pathogenesis of thoracic aortic aneurysms considering development and maintenance of the aortic root and how developmental regulations by Notch signaling may influence thoracic aortic aneurysms. • Notch is important in the embryonic development, postnatal maintenance of tissue homeostasis and response to stress. • Dysbalanced Notch is responsible for the loss of stress resistance in the aortic wall of aneurysmal tissues. • Elucidating the details of Notch disturbances could give therapeutic clues to cardiac pathologies.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Malashicheva A. В. et al. Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states // Biochimica et Biophysica Acta - Molecular Basis of Disease. 2020. Vol. 1866. No. 3. p. 165631.
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Malashicheva A. В., Kostina A., Kostareva A., Irtyuga O., Gordeev M., Uspensky V. Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states // Biochimica et Biophysica Acta - Molecular Basis of Disease. 2020. Vol. 1866. No. 3. p. 165631.
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TY - JOUR
DO - 10.1016/j.bbadis.2019.165631
UR - https://doi.org/10.1016%2Fj.bbadis.2019.165631
TI - Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states
T2 - Biochimica et Biophysica Acta - Molecular Basis of Disease
AU - Malashicheva, Anna В.
AU - Kostina, A.A.
AU - Kostareva, Anna
AU - Irtyuga, O.
AU - Gordeev, Mikhail
AU - Uspensky, Vladimir
PY - 2020
DA - 2020/03/01 00:00:00
PB - Elsevier
SP - 165631
IS - 3
VL - 1866
SN - 0925-4439
ER -
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@article{2020_Malashicheva,
author = {Anna В. Malashicheva and A.A. Kostina and Anna Kostareva and O. Irtyuga and Mikhail Gordeev and Vladimir Uspensky},
title = {Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states},
journal = {Biochimica et Biophysica Acta - Molecular Basis of Disease},
year = {2020},
volume = {1866},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016%2Fj.bbadis.2019.165631},
number = {3},
pages = {165631},
doi = {10.1016/j.bbadis.2019.165631}
}
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Malashicheva, Anna В., et al. “Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states.” Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1866, no. 3, Mar. 2020, p. 165631. https://doi.org/10.1016%2Fj.bbadis.2019.165631.
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