Behavioural Brain Research, volume 374, pages 112118

Modes of division and differentiation of neural stem cells

Lazutkin Alexander A. ^{1, 2, 3}

Podgorny Oleg ^{1, 4}

Enikolopov Grigori ¹

Hide authors affiliations Show authors affiliations: 4 affiliations

Center for Developmental Genetics and Department of Anesthesiology, Stony Brook University, Stony Brook, NY, United States |

Moscow Institute of Physics and Technology, Moscow, russia |

P.K. Anokhin Institute for Normal Physiology, Moscow, Russia. |

⁴

Koltzov Institute of Developmental Biology, Moscow, Russia. |

Publication type: Journal Article

Publication date: 2019-11-01

Elsevier

Journal: Behavioural Brain Research

Quartile SCImago

Quartile WOS

Impact factor: 2.7

ISSN: 01664328, 18727549

DOI: 10.1016/j.bbr.2019.112118

Copy DOI

Behavioral Neuroscience

Abstract

Hippocampal neurogenesis presents an unorthodox form of neuronal plasticity and may be relevant for the normal or abnormal functioning of the human and animal brain. As production of new neurons decreases after birth, purposefully activating stem cells to create additional new neurons may augment brain function or slow a disease's progression. Here, we describe current models of hippocampal stem cell maintenance and differentiation, and emphasize key features of neural stem cells' turnover that may define hippocampal neurogenesis enhancement attempts' long-term consequences. We argue that even the basic blueprint of how stem cells are maintained, divide, differentiate, and are eliminated is still contentious, with different models potentially leading to vastly different outcomes in regard to neuronal production and stem cell pool preservation. We propose that to manipulate neurogenesis for a long-term benefit, we must first understand the outline of the neural stem cells' lifecycle.

By date By citations

Citations by journals

	1 2 3 4
Cells	Cells, 4, 9.76% Cells 4 publications, 9.76%
Molecular Biotechnology	Molecular Biotechnology, 2, 4.88% Molecular Biotechnology 2 publications, 4.88%
Frontiers in Neuroscience	Frontiers in Neuroscience, 2, 4.88% Frontiers in Neuroscience 2 publications, 4.88%
Brain Sciences	Brain Sciences, 1, 2.44% Brain Sciences 1 publication, 2.44%
Nutrients	Nutrients, 1, 2.44% Nutrients 1 publication, 2.44%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 1, 2.44% Frontiers in Cell and Developmental Biology 1 publication, 2.44%
Frontiers in Genetics	Frontiers in Genetics, 1, 2.44% Frontiers in Genetics 1 publication, 2.44%
Frontiers in Cellular Neuroscience	Frontiers in Cellular Neuroscience, 1, 2.44% Frontiers in Cellular Neuroscience 1 publication, 2.44%
Bioengineering	Bioengineering, 1, 2.44% Bioengineering 1 publication, 2.44%
Scientific Reports	Scientific Reports, 1, 2.44% Scientific Reports 1 publication, 2.44%
Cellular and Molecular Neurobiology	Cellular and Molecular Neurobiology, 1, 2.44% Cellular and Molecular Neurobiology 1 publication, 2.44%
Experimental Brain Research	Experimental Brain Research, 1, 2.44% Experimental Brain Research 1 publication, 2.44%
World Neurosurgery	World Neurosurgery, 1, 2.44% World Neurosurgery 1 publication, 2.44%
Neuroscience Research	Neuroscience Research, 1, 2.44% Neuroscience Research 1 publication, 2.44%
Stress Biology	Stress Biology, 1, 2.44% Stress Biology 1 publication, 2.44%
Behavioural Brain Research	Behavioural Brain Research, 1, 2.44% Behavioural Brain Research 1 publication, 2.44%
Cell Stem Cell	Cell Stem Cell, 1, 2.44% Cell Stem Cell 1 publication, 2.44%
Cell Reports	Cell Reports, 1, 2.44% Cell Reports 1 publication, 2.44%
Journal of Neurochemistry	Journal of Neurochemistry, 1, 2.44% Journal of Neurochemistry 1 publication, 2.44%
iScience	iScience, 1, 2.44% iScience 1 publication, 2.44%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.44% International Journal of Molecular Sciences 1 publication, 2.44%
Neurochemical Journal	Neurochemical Journal, 1, 2.44% Neurochemical Journal 1 publication, 2.44%
MedComm	MedComm, 1, 2.44% MedComm 1 publication, 2.44%
CNS Neuroscience and Therapeutics	CNS Neuroscience and Therapeutics, 1, 2.44% CNS Neuroscience and Therapeutics 1 publication, 2.44%
Ibrain	Ibrain, 1, 2.44% Ibrain 1 publication, 2.44%
Developmental Neurobiology	Developmental Neurobiology, 1, 2.44% Developmental Neurobiology 1 publication, 2.44%
Journal of Functional Foods	Journal of Functional Foods, 1, 2.44% Journal of Functional Foods 1 publication, 2.44%
Journal of Neuroscience	Journal of Neuroscience, 1, 2.44% Journal of Neuroscience 1 publication, 2.44%
Molecular Neurobiology	Molecular Neurobiology, 1, 2.44% Molecular Neurobiology 1 publication, 2.44%

	1 2 3 4

Citations by publishers

	1 2 3 4 5 6 7 8 9
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 9, 21.95% Multidisciplinary Digital Publishing Institute (MDPI) 9 publications, 21.95%
Springer Nature	Springer Nature, 8, 19.51% Springer Nature 8 publications, 19.51%
Elsevier	Elsevier, 8, 19.51% Elsevier 8 publications, 19.51%
Frontiers Media S.A.	Frontiers Media S.A., 5, 12.2% Frontiers Media S.A. 5 publications, 12.2%
Wiley	Wiley, 5, 12.2% Wiley 5 publications, 12.2%
Pleiades Publishing	Pleiades Publishing, 1, 2.44% Pleiades Publishing 1 publication, 2.44%
Society for Neuroscience	Society for Neuroscience, 1, 2.44% Society for Neuroscience 1 publication, 2.44%
	1 2 3 4 5 6 7 8 9

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[7,8,9,16,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["17.07","19.51","21.95","39.02","2.44"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Cells","Molecular Biotechnology","Frontiers in Neuroscience","Brain Sciences","Nutrients","Frontiers in Cell and Developmental Biology","Frontiers in Genetics","Frontiers in Cellular Neuroscience","Bioengineering","Scientific Reports","Cellular and Molecular Neurobiology","Experimental Brain Research","World Neurosurgery","Neuroscience Research","Stress Biology","Behavioural Brain Research","Cell Stem Cell","Cell Reports","Journal of Neurochemistry","iScience","International Journal of Molecular Sciences","Neurochemical Journal","MedComm","CNS Neuroscience and Therapeutics","Ibrain","Developmental Neurobiology","Journal of Functional Foods","Journal of Neuroscience","Molecular Neurobiology"],"ids":[25293,8539,16373,3611,3372,12128,13242,17836,22376,13767,20077,23910,591,18137,29717,17416,13752,9130,12,6073,14627,25515,28715,21557,28606,687,13068,23913,24041],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/oK3sRIFs7jTQfHhJn9GNyct1rmZrCIj9Rn5x9It5_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[4,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[9.76,4.88,4.88,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","Elsevier","Frontiers Media S.A.","Wiley","Pleiades Publishing","Society for Neuroscience"],"ids":[202,8,17,208,11,101,3127],"codes":[0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/oK3sRIFs7jTQfHhJn9GNyct1rmZrCIj9Rn5x9It5_medium.webp"],"datasets":[{"label":"","data":[9,8,8,5,5,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[21.95,19.51,19.51,12.2,12.2,2.44,2.44],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Metrics

Cite this

GOST |

Cite this

GOST Copy

Lazutkin A. A. et al. Modes of division and differentiation of neural stem cells // Behavioural Brain Research. 2019. Vol. 374. p. 112118.

GOST all authors (up to 50) Copy

Lazutkin A. A., Podgorny O., Enikolopov G. Modes of division and differentiation of neural stem cells // Behavioural Brain Research. 2019. Vol. 374. p. 112118.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.bbr.2019.112118

UR - https://doi.org/10.1016%2Fj.bbr.2019.112118

TI - Modes of division and differentiation of neural stem cells

T2 - Behavioural Brain Research

AU - Lazutkin, Alexander A.

AU - Podgorny, Oleg

AU - Enikolopov, Grigori

PY - 2019

DA - 2019/11/01 00:00:00

PB - Elsevier

SP - 112118

VL - 374

SN - 0166-4328

SN - 1872-7549

ER -

BibTex

Cite this

BibTex Copy

@article{2019_Lazutkin,

author = {Alexander A. Lazutkin and Oleg Podgorny and Grigori Enikolopov},

title = {Modes of division and differentiation of neural stem cells},

journal = {Behavioural Brain Research},

year = {2019},

volume = {374},

publisher = {Elsevier},

month = {nov},

url = {https://doi.org/10.1016%2Fj.bbr.2019.112118},

pages = {112118},

doi = {10.1016/j.bbr.2019.112118}

}

Found error?

Publisher

Elsevier

Journal

Behavioural Brain Research

Quartile SCImago

Quartile WOS

Impact factor

2.7

ISSN

01664328 (Print)
18727549 (Electronic)

Labs

A group of brain stem cells

Profiles

Lazutkin, Alexander A