Biochimie, volume 219, pages 1-11
Interaction of Solanum tuberosum L. translation initiation factors eIF4E with potato virus Y VPg: Apprehend and avoid
Babakov Alexey
1
,
Kolesnikova Victoria
1, 2
,
Razhina Oksana L.
1
,
Zlobin Nikolay
1
,
Taranov Vasiliy
1
,
Nikonov Oleg
2
Publication type: Journal Article
Publication date: 2024-04-01
Biochemistry
General Medicine
Abstract
Potato virus Y (PVY) is one of the most dangerous agricultural pathogens that causes substantial harm to vegetative propagated crops, such as potatoes (Solanum tuberosum L.). A necessary condition for PVY infection is an interaction between the plant cap-binding translation initiation factors eIF4E and a viral protein VPg, which mimics the cap-structure. In this study, we identified the point mutations in potato eIF4E1 and eIF4E2 that disrupt VPg binding while preserving the functional activity. For the structural interpretation of the obtained results, molecular models of all the studied forms of eIF4E1 and eIF4E2 were constructed and analyzed via molecular dynamics. The results of molecular dynamics simulations corresponds to the biochemical results and suggests that the β1β2 loop plays a key role in the stabilization of both eIF4E–cap and eIF4E–VPg complexes.
Citations by journals
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Journal of Agricultural and Food Chemistry
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Journal of Agricultural and Food Chemistry
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Engineering Applications of Artificial Intelligence
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Engineering Applications of Artificial Intelligence
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Citations by publishers
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 50%
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Elsevier
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Elsevier
1 publication, 50%
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1
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Lebedeva M. V. et al. Interaction of Solanum tuberosum L. translation initiation factors eIF4E with potato virus Y VPg: Apprehend and avoid // Biochimie. 2024. Vol. 219. pp. 1-11.
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Lebedeva M. V., Nikonova E., Babakov A., Kolesnikova V., Razhina O. L., Zlobin N., Taranov V., Nikonov O. Interaction of Solanum tuberosum L. translation initiation factors eIF4E with potato virus Y VPg: Apprehend and avoid // Biochimie. 2024. Vol. 219. pp. 1-11.
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TY - JOUR
DO - 10.1016/j.biochi.2023.08.005
UR - https://doi.org/10.1016%2Fj.biochi.2023.08.005
TI - Interaction of Solanum tuberosum L. translation initiation factors eIF4E with potato virus Y VPg: Apprehend and avoid
T2 - Biochimie
AU - Lebedeva, Marina V
AU - Nikonova, Ekaterina
AU - Babakov, Alexey
AU - Kolesnikova, Victoria
AU - Razhina, Oksana L.
AU - Zlobin, Nikolay
AU - Taranov, Vasiliy
AU - Nikonov, Oleg
PY - 2024
DA - 2024/04/01 00:00:00
PB - Elsevier
SP - 1-11
VL - 219
SN - 0300-9084
SN - 6183-1638
ER -
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@article{2024_Lebedeva,
author = {Marina V Lebedeva and Ekaterina Nikonova and Alexey Babakov and Victoria Kolesnikova and Oksana L. Razhina and Nikolay Zlobin and Vasiliy Taranov and Oleg Nikonov},
title = {Interaction of Solanum tuberosum L. translation initiation factors eIF4E with potato virus Y VPg: Apprehend and avoid},
journal = {Biochimie},
year = {2024},
volume = {219},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016%2Fj.biochi.2023.08.005},
pages = {1--11},
doi = {10.1016/j.biochi.2023.08.005}
}