Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands
Publication type: Journal Article
Publication date: 2004-03-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
14980664
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A novel series of benzoxazole derivatives was synthesized and evaluated as melatoninergic ligands. The binding affinity of these compounds for human MT(1) and MT(2) receptors was determined using 2-[(125)I]-iodomelatonin as the radioligand. The results of the SAR studies in this series led to the identification of compound 28, which exhibited better MT(1) and MT(2) receptor affinities than melatonin itself. This work also established the benzoxazole nucleus as a melatoninergic pharmacophore, which served as an isosteric replacement to the previously established alkoxyaryl core.
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Metrics
57
Total citations:
57
Citations from 2024:
5
(8.77%)
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MLA
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GOST
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SUN L. et al. Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands // Bioorganic and Medicinal Chemistry Letters. 2004. Vol. 14. No. 5. pp. 1197-1200.
GOST all authors (up to 50)
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SUN L., Chen J., Takaki K., Johnson G., Iben L., Mahle C. D., Ryan E., Xu C. Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands // Bioorganic and Medicinal Chemistry Letters. 2004. Vol. 14. No. 5. pp. 1197-1200.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2003.12.052
UR - https://doi.org/10.1016/j.bmcl.2003.12.052
TI - Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands
T2 - Bioorganic and Medicinal Chemistry Letters
AU - SUN, LIQIANG
AU - Chen, Jie
AU - Takaki, Katherine
AU - Johnson, Graham
AU - Iben, Lawrence
AU - Mahle, Cathy D.
AU - Ryan, Elaine
AU - Xu, Cen
PY - 2004
DA - 2004/03/01
PB - Elsevier
SP - 1197-1200
IS - 5
VL - 14
PMID - 14980664
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2004_SUN,
author = {LIQIANG SUN and Jie Chen and Katherine Takaki and Graham Johnson and Lawrence Iben and Cathy D. Mahle and Elaine Ryan and Cen Xu},
title = {Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2004},
volume = {14},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.bmcl.2003.12.052},
number = {5},
pages = {1197--1200},
doi = {10.1016/j.bmcl.2003.12.052}
}
Cite this
MLA
Copy
SUN, LIQIANG, et al. “Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands.” Bioorganic and Medicinal Chemistry Letters, vol. 14, no. 5, Mar. 2004, pp. 1197-1200. https://doi.org/10.1016/j.bmcl.2003.12.052.