Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
Тип публикации: Journal Article
Дата публикации: 2008-03-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
18272363
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
We have explored a series of spirocyclic piperidine amide derivatives ( 5 ) as tryptase inhibitors. Thus, 4 (JNJ-27390467) was identified as a potent, selective tryptase inhibitor with oral efficacy in two animal models of airway inflammation (sheep and guinea pig asthma models). An X-ray co-crystal structure of 4 · tryptase revealed a hydrophobic pocket in the enzyme’s active site, which is induced by the phenylethynyl group and is comprised of amino acid residues from two different monomers of the tetrameric protein.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.
Топ-30
Журналы
|
1
2
3
4
|
|
|
Angewandte Chemie - International Edition
4 публикации, 8.16%
|
|
|
Angewandte Chemie
4 публикации, 8.16%
|
|
|
Journal of Organic Chemistry
3 публикации, 6.12%
|
|
|
Pharmacology and Therapeutics
3 публикации, 6.12%
|
|
|
Tetrahedron Letters
3 публикации, 6.12%
|
|
|
Bioorganic and Medicinal Chemistry Letters
2 публикации, 4.08%
|
|
|
Advances in Immunology
2 публикации, 4.08%
|
|
|
Molecules
2 публикации, 4.08%
|
|
|
Chemistry - An Asian Journal
1 публикация, 2.04%
|
|
|
Journal of Biomolecular Structure and Dynamics
1 публикация, 2.04%
|
|
|
Naunyn-Schmiedeberg's Archives of Pharmacology
1 публикация, 2.04%
|
|
|
PLoS ONE
1 публикация, 2.04%
|
|
|
Bioorganic and Medicinal Chemistry
1 публикация, 2.04%
|
|
|
Tetrahedron
1 публикация, 2.04%
|
|
|
ChemCatChem
1 публикация, 2.04%
|
|
|
Chemistry - A European Journal
1 публикация, 2.04%
|
|
|
Helvetica Chimica Acta
1 публикация, 2.04%
|
|
|
Biopolymers
1 публикация, 2.04%
|
|
|
Organic Letters
1 публикация, 2.04%
|
|
|
Journal of Medicinal Chemistry
1 публикация, 2.04%
|
|
|
Journal of the American Chemical Society
1 публикация, 2.04%
|
|
|
MedChemComm
1 публикация, 2.04%
|
|
|
Chemical Communications
1 публикация, 2.04%
|
|
|
Chemical Science
1 публикация, 2.04%
|
|
|
Expert Opinion on Therapeutic Patents
1 публикация, 2.04%
|
|
|
G3: Genes, Genomes, Genetics
1 публикация, 2.04%
|
|
|
Annual Reports in Medicinal Chemistry
1 публикация, 2.04%
|
|
|
Organic Chemistry Frontiers
1 публикация, 2.04%
|
|
|
Science China Chemistry
1 публикация, 2.04%
|
|
|
1
2
3
4
|
Издатели
|
2
4
6
8
10
12
14
16
|
|
|
Elsevier
15 публикаций, 30.61%
|
|
|
Wiley
14 публикаций, 28.57%
|
|
|
American Chemical Society (ACS)
6 публикаций, 12.24%
|
|
|
Royal Society of Chemistry (RSC)
4 публикации, 8.16%
|
|
|
Springer Nature
3 публикации, 6.12%
|
|
|
Taylor & Francis
2 публикации, 4.08%
|
|
|
MDPI
2 публикации, 4.08%
|
|
|
Public Library of Science (PLoS)
1 публикация, 2.04%
|
|
|
Oxford University Press
1 публикация, 2.04%
|
|
|
2
4
6
8
10
12
14
16
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
49
Всего цитирований:
49
Цитирований c 2025:
4
(8.16%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Costanzo M. J. et al. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 6. pp. 2114-2121.
ГОСТ со всеми авторами (до 50)
Скопировать
Costanzo M. J., Yabut S. C., Li X., White K. B., de Garavilla L., Wang Y., Minor L. K., Tounge B. A., Barnakov A. N., Lewandowski F., Milligan C., Spurlino J. C., ABRAHAM W. M., Boswell-Smith V., PAGE C. J., Maryanoff B. E. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 6. pp. 2114-2121.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1016/j.bmcl.2008.01.093
UR - https://doi.org/10.1016/j.bmcl.2008.01.093
TI - Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Costanzo, Michael J
AU - Yabut, Stephen C
AU - Li, Xiaohui
AU - White, Kimberley B
AU - de Garavilla, Lawrence
AU - Wang, Yuan-Ping
AU - Minor, Lisa K.
AU - Tounge, Brett A.
AU - Barnakov, Alexander N.
AU - Lewandowski, Frank
AU - Milligan, Cynthia
AU - Spurlino, John C.
AU - ABRAHAM, WILLIAM M.
AU - Boswell-Smith, Victoria
AU - PAGE, C. J.
AU - Maryanoff, Bruce E
PY - 2008
DA - 2008/03/01
PB - Elsevier
SP - 2114-2121
IS - 6
VL - 18
PMID - 18272363
SN - 0960-894X
SN - 1464-3405
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2008_Costanzo,
author = {Michael J Costanzo and Stephen C Yabut and Xiaohui Li and Kimberley B White and Lawrence de Garavilla and Yuan-Ping Wang and Lisa K. Minor and Brett A. Tounge and Alexander N. Barnakov and Frank Lewandowski and Cynthia Milligan and John C. Spurlino and WILLIAM M. ABRAHAM and Victoria Boswell-Smith and C. J. PAGE and Bruce E Maryanoff},
title = {Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2008},
volume = {18},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.bmcl.2008.01.093},
number = {6},
pages = {2114--2121},
doi = {10.1016/j.bmcl.2008.01.093}
}
Цитировать
MLA
Скопировать
Costanzo, Michael J., et al. “Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives..” Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 6, Mar. 2008, pp. 2114-2121. https://doi.org/10.1016/j.bmcl.2008.01.093.