Bioorganic and Medicinal Chemistry Letters

, том 18 , издание 24 , страницы 6568-6572

Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results

Тип публикации: Journal Article

Дата публикации: 2008-12-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

БС2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/j.bmcl.2008.10.040

Скопировать DOI

PubMed ID: 19008098

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Краткое описание

Bacterial peptide deformylase (PDF) belongs to a subfamily of metalloproteases catalyzing the removal of the N-terminal formyl group from newly synthesized proteins. We report the synthesis and biological activity of highly potent inhibitors of Mycobacterium tuberculosis (Mtb) PDF enzyme as well as the first X-ray crystal structure of Mtb PDF. Structure-activity relationship and crystallographic data clarified the structural requirements for high enzyme potency and cell based potency. Activities against single and multi-drug-resistant Mtb strains are also reported.

Найдено

1 цитирование

Кохен Сетх

PhD, ассистент

414 публикаций, 34 597 цитирований, 169 рецензий

Индекс Хирша: 93

Калифорнийский университет в Сан-Диего

Области научных интересов

Биоорганическая химия

Медицинская химия

Метал-органические каркасы

Неорганическая химия

Супрамолекулярная химия

Топ-30

Журналы

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European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 3, 8.11% European Journal of Medicinal Chemistry 3 публикации, 8.11%
Molecules	Molecules, 2, 5.41% Molecules 2 публикации, 5.41%
Bioorganic and Medicinal Chemistry Letters	Bioorganic and Medicinal Chemistry Letters, 2, 5.41% Bioorganic and Medicinal Chemistry Letters 2 публикации, 5.41%
Acta Crystallographica Section D Biological Crystallography	Acta Crystallographica Section D Biological Crystallography, 1, 2.7% Acta Crystallographica Section D Biological Crystallography 1 публикация, 2.7%
Future Medicinal Chemistry	Future Medicinal Chemistry, 1, 2.7% Future Medicinal Chemistry 1 публикация, 2.7%
Antibiotics	Antibiotics, 1, 2.7% Antibiotics 1 публикация, 2.7%
Frontiers in Immunology	Frontiers in Immunology, 1, 2.7% Frontiers in Immunology 1 публикация, 2.7%
Medicinal Chemistry Research	Medicinal Chemistry Research, 1, 2.7% Medicinal Chemistry Research 1 публикация, 2.7%
Scientific Reports	Scientific Reports, 1, 2.7% Scientific Reports 1 публикация, 2.7%
Nature Reviews Microbiology	Nature Reviews Microbiology, 1, 2.7% Nature Reviews Microbiology 1 публикация, 2.7%
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Elsevier	Elsevier, 10, 27.03% Elsevier 10 публикаций, 27.03%
Wiley	Wiley, 7, 18.92% Wiley 7 публикаций, 18.92%
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Taylor & Francis	Taylor & Francis, 3, 8.11% Taylor & Francis 3 публикации, 8.11%
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American Chemical Society (ACS)	American Chemical Society (ACS), 3, 8.11% American Chemical Society (ACS) 3 публикации, 8.11%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 2, 5.41% International Union of Crystallography (IUCr) 2 публикации, 5.41%
American Society for Microbiology	American Society for Microbiology, 2, 5.41% American Society for Microbiology 2 публикации, 5.41%
Frontiers Media S.A.	Frontiers Media S.A., 1, 2.7% Frontiers Media S.A. 1 публикация, 2.7%
Oxford University Press	Oxford University Press, 1, 2.7% Oxford University Press 1 публикация, 2.7%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 2.7% Cold Spring Harbor Laboratory 1 публикация, 2.7%
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Pichota A. et al. Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 24. pp. 6568-6572.

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Pichota A., Duraiswamy J., Yin Z., Keller T. M., Alam J., Liung S., Lee G., Ding M., Wang G., Chan W. L. M., Schreiber M., Ma I., Beer D. G., Ngew X., Mukherjee K., Nanjundappa M., Teo J. W. P., Thayalan P., Yap A., Dick T. E., Meng W., Xu M., Koehn J., Pan S., CLARK K., Xie X., Shoen C., Cynamon M. H. Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 24. pp. 6568-6572.

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TY - JOUR

DO - 10.1016/j.bmcl.2008.10.040

UR - https://doi.org/10.1016/j.bmcl.2008.10.040

TI - Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Pichota, Arkadius

AU - Duraiswamy, Jeyaraj

AU - Yin, Zheng

AU - Keller, Thomas M.

AU - Alam, Jenefer

AU - Liung, Sarah

AU - Lee, Gladys

AU - Ding, M.

AU - Wang, Gang

AU - Chan, Wai Leong Mickey

AU - Schreiber, Mark

AU - Ma, Ida

AU - Beer, David G.

AU - Ngew, Xinyi

AU - Mukherjee, Kakoli

AU - Nanjundappa, Mahesh

AU - Teo, Jeanette W. P.

AU - Thayalan, Pamela

AU - Yap, Amelia

AU - Dick, T E

AU - Meng, Wuyi

AU - Xu, Mei

AU - Koehn, James

AU - Pan, Shi-hao

AU - CLARK, Kirk

AU - Xie, Xiaoling

AU - Shoen, Carolyn

AU - Cynamon, M. H.

PY - 2008

DA - 2008/12/01

PB - Elsevier

SP - 6568-6572

IS - 24

VL - 18

PMID - 19008098

SN - 0960-894X

SN - 1464-3405

ER -

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@article{2008_Pichota,

author = {Arkadius Pichota and Jeyaraj Duraiswamy and Zheng Yin and Thomas M. Keller and Jenefer Alam and Sarah Liung and Gladys Lee and M. Ding and Gang Wang and Wai Leong Mickey Chan and Mark Schreiber and Ida Ma and David G. Beer and Xinyi Ngew and Kakoli Mukherjee and Mahesh Nanjundappa and Jeanette W. P. Teo and Pamela Thayalan and Amelia Yap and T E Dick and Wuyi Meng and Mei Xu and James Koehn and Shi-hao Pan and Kirk CLARK and Xiaoling Xie and Carolyn Shoen and M. H. Cynamon},

title = {Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {2008},

volume = {18},

publisher = {Elsevier},

month = {dec},

url = {https://doi.org/10.1016/j.bmcl.2008.10.040},

number = {24},

pages = {6568--6572},

doi = {10.1016/j.bmcl.2008.10.040}

}

MLA

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MLA Скопировать

Pichota, Arkadius, et al. “Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results.” Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 24, Dec. 2008, pp. 6568-6572. https://doi.org/10.1016/j.bmcl.2008.10.040.

Издатель

Elsevier

Журнал

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

БС2

SJR

0.472

CiteScore

5.1

Impact factor

2.2

ISSN

0960894X (Print)

14643405 (Electronic)