Discovery of highly potent and selective type I B-Raf kinase inhibitors
Xiaolun Wang
1
,
Dan M Berger
1
,
Edward J. Salaski
1
,
Nancy Torres
1
,
Yongbo Hu
1
,
Jeremy I Levin
1
,
Dennis Powell
1
,
Donald Wojciechowicz
2
,
Karen Scott Collins
2
,
Eileen Frommer
2
1
Chemical Sciences, Wyeth Research, 401 N. Middletown Road., Pearl River, NY 10965, USA
|
2
Discovery Oncology, Wyeth Research, 401 N. Middletown Road., Pearl River, NY 10965, USA
|
Publication type: Journal Article
Publication date: 2009-12-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
19854649
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A series of pyrazolo[1,5-alpha]pyrimidine analogs has been prepared and found to be potent and selective B-Raf inhibitors. Molecular modeling suggests they bind to the active conformation of the enzyme.
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Total citations:
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Citations from 2024:
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(4.17%)
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MLA
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GOST
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Wang X. et al. Discovery of highly potent and selective type I B-Raf kinase inhibitors // Bioorganic and Medicinal Chemistry Letters. 2009. Vol. 19. No. 23. pp. 6571-6574.
GOST all authors (up to 50)
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Wang X., Berger D. M., Salaski E. J., Torres N., Hu Y., Levin J. I., Powell D., Wojciechowicz D., Collins K. S., Frommer E. Discovery of highly potent and selective type I B-Raf kinase inhibitors // Bioorganic and Medicinal Chemistry Letters. 2009. Vol. 19. No. 23. pp. 6571-6574.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2009.10.030
UR - https://doi.org/10.1016/j.bmcl.2009.10.030
TI - Discovery of highly potent and selective type I B-Raf kinase inhibitors
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Wang, Xiaolun
AU - Berger, Dan M
AU - Salaski, Edward J.
AU - Torres, Nancy
AU - Hu, Yongbo
AU - Levin, Jeremy I
AU - Powell, Dennis
AU - Wojciechowicz, Donald
AU - Collins, Karen Scott
AU - Frommer, Eileen
PY - 2009
DA - 2009/12/01
PB - Elsevier
SP - 6571-6574
IS - 23
VL - 19
PMID - 19854649
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2009_Wang,
author = {Xiaolun Wang and Dan M Berger and Edward J. Salaski and Nancy Torres and Yongbo Hu and Jeremy I Levin and Dennis Powell and Donald Wojciechowicz and Karen Scott Collins and Eileen Frommer},
title = {Discovery of highly potent and selective type I B-Raf kinase inhibitors},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2009},
volume = {19},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.bmcl.2009.10.030},
number = {23},
pages = {6571--6574},
doi = {10.1016/j.bmcl.2009.10.030}
}
Cite this
MLA
Copy
Wang, Xiaolun, et al. “Discovery of highly potent and selective type I B-Raf kinase inhibitors.” Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 23, Dec. 2009, pp. 6571-6574. https://doi.org/10.1016/j.bmcl.2009.10.030.