Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula
Koneni V Sashidhara
1
,
Suriya P Singh
1
,
Ruchir Kant
2
,
Prakas R. Maulik
2
,
Jayanta Sarkar
3
,
Sanjeev Kanojiya
4
,
K. Ravi Kumar
5
Publication type: Journal Article
Publication date: 2010-10-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
20732814
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A 24-methylenecycloartane-3 β, 16 β, 23 β-triol, Longitriol (1), rare bisclerodane imides, Longimide A (2) and previously known Longimide B (3) were isolated from ethanolic extract of the leaves of Polyalthia longifolia var. pendula. This is the first example of isolation of any cycloartane triterpene from this plant source. Structures were determined by extensive (1D and 2D NMR) spectroscopic data analysis combined with ESI MS/MS fragmentation and X-ray analysis. Furthermore, Compounds 1 and 2 were evaluated for their cytotoxic effects against four human cancer cell lines and found to be most active against cervical carcinoma cell lines with IC(50) value of 10.03 and 4.12 μg/mL, respectively.
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Total citations:
33
Citations from 2024:
3
(9.09%)
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GOST
Copy
Sashidhara K. V. et al. Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula // Bioorganic and Medicinal Chemistry Letters. 2010. Vol. 20. No. 19. pp. 5767-5771.
GOST all authors (up to 50)
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Sashidhara K. V., Singh S. P., Kant R., Maulik P. R., Sarkar J., Kanojiya S., Ravi Kumar K. Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula // Bioorganic and Medicinal Chemistry Letters. 2010. Vol. 20. No. 19. pp. 5767-5771.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2010.07.141
UR - https://doi.org/10.1016/j.bmcl.2010.07.141
TI - Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Sashidhara, Koneni V
AU - Singh, Suriya P
AU - Kant, Ruchir
AU - Maulik, Prakas R.
AU - Sarkar, Jayanta
AU - Kanojiya, Sanjeev
AU - Ravi Kumar, K.
PY - 2010
DA - 2010/10/01
PB - Elsevier
SP - 5767-5771
IS - 19
VL - 20
PMID - 20732814
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2010_Sashidhara,
author = {Koneni V Sashidhara and Suriya P Singh and Ruchir Kant and Prakas R. Maulik and Jayanta Sarkar and Sanjeev Kanojiya and K. Ravi Kumar},
title = {Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2010},
volume = {20},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.bmcl.2010.07.141},
number = {19},
pages = {5767--5771},
doi = {10.1016/j.bmcl.2010.07.141}
}
Cite this
MLA
Copy
Sashidhara, Koneni V., et al. “Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula.” Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 19, Oct. 2010, pp. 5767-5771. https://doi.org/10.1016/j.bmcl.2010.07.141.