New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv
Olga I. Yarovaya
1
,
Kseniya Kovaleva
1
,
Anna V. Zaykovskaya
2
,
Liudmila N. Yashina
2
,
Nadezda S Scherbakova
2
,
Dmitry N Scherbakov
2
,
Fedor I. Zubkov
4
,
Roman Yu Peshkov
5
,
Ilia V. Eltsov
5
,
О. В. Пьянков
2
,
Irina V Kolosova
2
,
3
Publication type: Journal Article
Publication date: 2021-05-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
33705902
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
This work presents the design and synthesis of camphor, fenchone, and norcamphor N -acylhydrazone derivatives as a new class of inhibitors of the Hantaan virus, which causes haemorrhagic fever with renal syndrome (HFRS). A cytopathic model was developed for testing chemotherapeutics against the Hantaan virus, strain 76–118. In addition, a study of the antiviral activity was carried out using a pseudoviral system. It was found that the hit compound possesses significant activity (IC 50 = 7.6 ± 2 µM) along with low toxicity (CC 50 > 1000 µM). Using molecular docking procedures, the binding with Hantavirus nucleoprotein was evaluated and the correlation between the structure of the synthesised compounds and the antiviral activity was established.
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15
Total citations:
15
Citations from 2024:
8
(53.33%)
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Yarovaya O. I. et al. New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv // Bioorganic and Medicinal Chemistry Letters. 2021. Vol. 40. p. 127926.
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Yarovaya O. I., Kovaleva K., Zaykovskaya A. V., Yashina L. N., Scherbakova N. S., Scherbakov D. N., Borisevich S. S., Zubkov F. I., Antonova A. S., Peshkov R. Yu., Eltsov I. V., Пьянков О. В., Kolosova I. V., Salakhutdinov N. F. New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv // Bioorganic and Medicinal Chemistry Letters. 2021. Vol. 40. p. 127926.
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RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2021.127926
UR - https://doi.org/10.1016/j.bmcl.2021.127926
TI - New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Yarovaya, Olga I.
AU - Kovaleva, Kseniya
AU - Zaykovskaya, Anna V.
AU - Yashina, Liudmila N.
AU - Scherbakova, Nadezda S
AU - Scherbakov, Dmitry N
AU - Borisevich, Sophia S.
AU - Zubkov, Fedor I.
AU - Antonova, Alexandra S
AU - Peshkov, Roman Yu
AU - Eltsov, Ilia V.
AU - Пьянков, О. В.
AU - Kolosova, Irina V
AU - Salakhutdinov, Nariman F.
PY - 2021
DA - 2021/05/01
PB - Elsevier
SP - 127926
VL - 40
PMID - 33705902
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (up to 50 authors)
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@article{2021_Yarovaya,
author = {Olga I. Yarovaya and Kseniya Kovaleva and Anna V. Zaykovskaya and Liudmila N. Yashina and Nadezda S Scherbakova and Dmitry N Scherbakov and Sophia S. Borisevich and Fedor I. Zubkov and Alexandra S Antonova and Roman Yu Peshkov and Ilia V. Eltsov and О. В. Пьянков and Irina V Kolosova and Nariman F. Salakhutdinov},
title = {New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2021},
volume = {40},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.bmcl.2021.127926},
pages = {127926},
doi = {10.1016/j.bmcl.2021.127926}
}