Carbohydrate Polymers, volume 252, pages 117181
Interaction-induced structural transformation of lysozyme and kappa-carrageenan in binary complexes
Makshakova O N
,
Makshakova Olga
1
,
Bogdanova L R
1, 2
,
Faizullin D A
,
Ermakova E A
,
Ermakova Elena P.
1, 2
,
Zuev Yu F
,
Zuev Yuriy F.
3
,
Sedov Igor A.
2, 4
,
Sedov I A
Publication type: Journal Article
Publication date: 2021-01-01
Journal:
Carbohydrate Polymers
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 11.2
ISSN: 01448617, 18791344
Materials Chemistry
Organic Chemistry
Polymers and Plastics
Abstract
The interactions between κ-carrageenan and hen egg-white lysozyme have been studied. In dilute solutions, the insoluble complexes with constant κ-carrageenan/lysozyme ratio of 0.3, or 12 disaccharide units per mole of protein are formed. FTIR-spectroscopy revealed that κ-carrageenan retains its unordered conformation and induces the rise of β-structure in lysozyme. In the complexes formed in concentrated mixtures, κ-carrageenan adopts helical conformation and lysozyme retains its native-like structure. These complexes contain 21 disaccharide units per mole of protein. Molecular modeling showed that flexible coil and rigid double helix of κ-carrageenan have different binding patterns to lysozyme surface. The latter has a strong preference to positively charged spots in lysozyme α-domain while the former also interacts to protein β-domain and stabilizes short-living β-structures. The obtained results confirm the preference of unordered κ-carrageenan to β-structure rich protein regions, which can be further used in the development of carrageenan-based protection of amyloid-like aggregation of proteins.
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- We do not take into account publications that without a DOI.
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Makshakova O. N. et al. Interaction-induced structural transformation of lysozyme and kappa-carrageenan in binary complexes // Carbohydrate Polymers. 2021. Vol. 252. p. 117181.
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Makshakova O. N., Makshakova O., Bogdanova L. R., Faizullin D. A., Faizullin D. A., Ermakova E. A., Ermakova E. P., Zuev Yu. F., Zuev Y. F., Sedov I. A., Sedov I. A. Interaction-induced structural transformation of lysozyme and kappa-carrageenan in binary complexes // Carbohydrate Polymers. 2021. Vol. 252. p. 117181.
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TY - JOUR
DO - 10.1016/j.carbpol.2020.117181
UR - https://doi.org/10.1016%2Fj.carbpol.2020.117181
TI - Interaction-induced structural transformation of lysozyme and kappa-carrageenan in binary complexes
T2 - Carbohydrate Polymers
AU - Makshakova, O N
AU - Bogdanova, L R
AU - Faizullin, D A
AU - Ermakova, E A
AU - Zuev, Yu F
AU - Sedov, I A
AU - Makshakova, Olga
AU - Faizullin, Dzhigangir A.
AU - Ermakova, Elena P.
AU - Zuev, Yuriy F.
AU - Sedov, Igor A.
PY - 2021
DA - 2021/01/01 00:00:00
PB - Elsevier
SP - 117181
VL - 252
SN - 0144-8617
SN - 1879-1344
ER -
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@article{2021_Makshakova,
author = {O N Makshakova and L R Bogdanova and D A Faizullin and E A Ermakova and Yu F Zuev and I A Sedov and Olga Makshakova and Dzhigangir A. Faizullin and Elena P. Ermakova and Yuriy F. Zuev and Igor A. Sedov},
title = {Interaction-induced structural transformation of lysozyme and kappa-carrageenan in binary complexes},
journal = {Carbohydrate Polymers},
year = {2021},
volume = {252},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.carbpol.2020.117181},
pages = {117181},
doi = {10.1016/j.carbpol.2020.117181}
}
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