Cell

, volume 182 , issue 4 , pages 812-827.e19

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Bette Korber ¹

Will Fischer ²

S. Gnanakaran ²

Hyejin Yoon ²

James Theiler ²

Werner Abfalterer ²

Nick Hengartner ²

Elena E. Giorgi ²

Tanmoy Bhattacharya ²

Brian Foley ²

Kathryn Hastie ³

Matthew D Parker ⁴

David G. Partridge ⁵

Cariad M Evans ⁵

Timothy M Freeman ⁴

Thushan de Silva ⁶

Charlene McDanal ⁷

Rebecca Nelson Brown ⁷

Haili Tang ⁷

Luke R. Green ^{8, 9, 10}

Celia C. LaBranche ¹¹

Paul Parsons ⁷

Benjamin B. Lindsey ⁷

Paul J Parsons ⁷

Raza Mohammad ⁷

Alex Moon Walker ^{8, 9, 10}

Sean Whelan ¹¹

Celia LaBranche ⁷

Erica Saphire ³

David C. Montefiori ⁷

Hide authors affiliations Show authors affiliations: 11 affiliations

Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA |

Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA. |

La Jolla Institute for Immunology, La Jolla, CA 92037, USA |

⁴

Sheffield Biomedical Research Centre & Sheffield Bioinformatics Core, University of Sheffield, Sheffield S10 2HQ, UK. |

⁵

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK |

⁶

Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, S10 2RX UK |

⁷

Duke Human Vaccine Institute & Department of Surgery, Durham, NC 27710, USA |

⁸

Department of Molecular Microbiology, Washington University in Saint Louis, St. Louis, MO 63130, USA |

⁹

La Jolla Institute for Immunology, La Jolla, CA 92037 USA |

¹⁰

Program in Virology, Harvard University, Boston, MA 02115 USA |

¹¹

Department of Molecular Microbiology, Washington University in Saint Louis, St. Louis MO 63130 USA |

Publication type: Journal Article

Publication date: 2020-08-01

Elsevier

Cell

scimago Q1

wos Q1

SJR: 22.612

CiteScore: 74.8

Impact factor: 42.5

ISSN: 00928674, 10974172

DOI: 10.1016/j.cell.2020.06.043

Copy DOI

PubMed ID: 32697968

General Biochemistry, Genetics and Molecular Biology

Abstract

A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal. The shift occurred even in local epidemics where the original D614 form was well established prior to introduction of the G614 variant. The consistency of this pattern was highly statistically significant, suggesting that the G614 variant may have a fitness advantage. We found that the G614 variant grows to a higher titer as pseudotyped virions. In infected individuals, G614 is associated with lower RT-PCR cycle thresholds, suggestive of higher upper respiratory tract viral loads, but not with increased disease severity. These findings illuminate changes important for a mechanistic understanding of the virus and support continuing surveillance of Spike mutations to aid with development of immunological interventions.

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Cite this

GOST |

Cite this

GOST Copy

Korber B. et al. Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus // Cell. 2020. Vol. 182. No. 4. p. 812-827.e19.

GOST all authors (up to 50) Copy

Korber B., Fischer W., Gnanakaran S., Yoon H., Theiler J., Abfalterer W., Hengartner N., Giorgi E. E., Bhattacharya T., Foley B., Hastie K., Parker M. D., Partridge D. G., Evans C. M., Freeman T. M., de Silva T., McDanal C., Brown R. N., Tang H., Green L. R., LaBranche C. C., Parsons P., Lindsey B. B., Parsons P. J., Mohammad R., Moon Walker A., Whelan S., LaBranche C., Saphire E., Montefiori D. C. Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus // Cell. 2020. Vol. 182. No. 4. p. 812-827.e19.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.cell.2020.06.043

UR - https://doi.org/10.1016/j.cell.2020.06.043

TI - Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

T2 - Cell

AU - Korber, Bette

AU - Fischer, Will

AU - Gnanakaran, S.

AU - Yoon, Hyejin

AU - Theiler, James

AU - Abfalterer, Werner

AU - Hengartner, Nick

AU - Giorgi, Elena E.

AU - Bhattacharya, Tanmoy

AU - Foley, Brian

AU - Hastie, Kathryn

AU - Parker, Matthew D

AU - Partridge, David G.

AU - Evans, Cariad M

AU - Freeman, Timothy M

AU - de Silva, Thushan

AU - McDanal, Charlene

AU - Brown, Rebecca Nelson

AU - Tang, Haili

AU - Green, Luke R.

AU - LaBranche, Celia C.

AU - Parsons, Paul

AU - Lindsey, Benjamin B.

AU - Parsons, Paul J

AU - Mohammad, Raza

AU - Moon Walker, Alex

AU - Whelan, Sean

AU - LaBranche, Celia

AU - Saphire, Erica

AU - Montefiori, David C.

PY - 2020

DA - 2020/08/01

PB - Elsevier

SP - 812-827.e19

IS - 4

VL - 182

PMID - 32697968

SN - 0092-8674

SN - 1097-4172

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Korber,

author = {Bette Korber and Will Fischer and S. Gnanakaran and Hyejin Yoon and James Theiler and Werner Abfalterer and Nick Hengartner and Elena E. Giorgi and Tanmoy Bhattacharya and Brian Foley and Kathryn Hastie and Matthew D Parker and David G. Partridge and Cariad M Evans and Timothy M Freeman and Thushan de Silva and Charlene McDanal and Rebecca Nelson Brown and Haili Tang and Luke R. Green and Celia C. LaBranche and Paul Parsons and Benjamin B. Lindsey and Paul J Parsons and Raza Mohammad and Alex Moon Walker and Sean Whelan and Celia LaBranche and Erica Saphire and David C. Montefiori},

title = {Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus},

journal = {Cell},

year = {2020},

volume = {182},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016/j.cell.2020.06.043},

number = {4},

pages = {812--827.e19},

doi = {10.1016/j.cell.2020.06.043}

}

MLA

Cite this

MLA Copy

Korber, Bette, et al. “Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.” Cell, vol. 182, no. 4, Aug. 2020, pp. 812-827.e19. https://doi.org/10.1016/j.cell.2020.06.043.

Publisher

Elsevier

Journal

Cell

scimago Q1

wos Q1

SJR

22.612

CiteScore

74.8

Impact factor

42.5

ISSN

00928674 (Print)

10974172 (Electronic)