Applied Clay Science, volume 184, pages 105401
Peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates with different morphologies
Publication type: Journal Article
Publication date: 2020-01-01
Geochemistry and Petrology
Geology
Abstract
The peculiarities of the adsorption of the anticancer drug, 5-fluorouracil, by aluminosilicate matrices with different morphologies — BEA zeolites, layered silicates with saponite (Mg3Si4O10(OH)2.H2O) and montmorillonite (Na0.2Al1.8Mg0.2Si4O10(OH)2.H2O) structures, and nanotubular halloysites (Al2Si2O5(OH)4.2H2O) were investigated. The influence of the polarity of the solvent used (water, acetone, and ethanol), pH-environment (pH = 5, 8, and 11), morphology (framed, layered, and nanotubular), and chemical composition (Al2O3 content 0–40 wt%) of the initial matrix on the amount of the adsorbed drug was studied. To prevent errors associated with the possibility of the existence of various tautomeric forms of fluorouracil in solutions, the adsorption processes were exclusively analysed using thermal analysis coupled with mass spectrometry. The efficiency of 5-fluorouracil adsorption and the loading conditions are largely determined by the chemical composition of the initial aluminosilicate matrix and its morphology. Zeolite exhibited the highest adsorption capacity for fluorouracil under any saturation conditions, while the halloysite matrix showed the lowest capacity.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Golubeva O. Yu. et al. Peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates with different morphologies // Applied Clay Science. 2020. Vol. 184. p. 105401.
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Golubeva O. Yu., Alikina Y. A., Brazovskaya E. Yu., Ugolkov V. V. Peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates with different morphologies // Applied Clay Science. 2020. Vol. 184. p. 105401.
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TY - JOUR
DO - 10.1016/j.clay.2019.105401
UR - https://doi.org/10.1016%2Fj.clay.2019.105401
TI - Peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates with different morphologies
T2 - Applied Clay Science
AU - Golubeva, Olga Yu
AU - Alikina, Yulia A
AU - Brazovskaya, Elena Yu
AU - Ugolkov, Valery V
PY - 2020
DA - 2020/01/01 00:00:00
PB - Elsevier
SP - 105401
VL - 184
SN - 0169-1317
ER -
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@article{2020_Golubeva,
author = {Olga Yu Golubeva and Yulia A Alikina and Elena Yu Brazovskaya and Valery V Ugolkov},
title = {Peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates with different morphologies},
journal = {Applied Clay Science},
year = {2020},
volume = {184},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.clay.2019.105401},
pages = {105401},
doi = {10.1016/j.clay.2019.105401}
}