Elsevier
Clinical Colorectal Cancer
,  volume 24 ,  issue 1 ,  pages 1-100000

Chemotherapy Rechallenge or Reintroduction compared to Regorafenib or Trifluridine/Tipiracil for pretreated metastatic colorectal cancer patients: a PROpensity ScorE analysis of tReatment beYond secoNd line (PROSERpYNa Study)

M.A. Calegari 1
, 
I.V. Zurlo 2
, 
Emanuela Dell’Aquila 3
, 
M. BASSO 4
, 
A Orlandi 4
, 
M. Bensi 5
, 
F Camarda 5
, 
A Anghelone 5
, 
Carmelo Pozzo 4
, 
Isabella Sperduti 6
, 
L Salvatore 5
, 
D. SANTINI 7
, 
Domenico Cristiano Corsi 2
, 
E. Bria 5
, 
G. Tortora 5
1
 
2
 
3
 
4
 
5
 
6
 
Biostatistics, IRCCS Regina Elena National Cancer Institute, Roma, Italy. | 
7
 
Publication type: Journal Article
Publication date: 2025-03-01
Elsevier
scimago Q1
wos Q2
SJR: 1.187
CiteScore: 6.2
Impact factor: 3.2
ISSN: 15330028, 19380674
Abstract
The optimal treatment for metastatic colorectal cancer (mCRC) beyond second line is still questioned. Besides the standard of care agents (regorafenib, REG, or trifluridine/tipiracil, FTD/TPI), chemotherapy rechallenge or reintroduction (CTr/r) are commonly considered in clinical practice, despite weak supporting evidence. The prognostic performance of CTr/r, REG and FTD/TPI in this setting are herein evaluated.
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GOST Copy
Calegari M. et al. Chemotherapy Rechallenge or Reintroduction compared to Regorafenib or Trifluridine/Tipiracil for pretreated metastatic colorectal cancer patients: a PROpensity ScorE analysis of tReatment beYond secoNd line (PROSERpYNa Study) // Clinical Colorectal Cancer. 2025. Vol. 24. No. 1. pp. 1-100000.
GOST all authors (up to 50) Copy
Calegari M., Zurlo I., Dell’Aquila E., BASSO M., Orlandi A., Bensi M., Camarda F., Anghelone A., Pozzo C., Sperduti I., Salvatore L., SANTINI D., Corsi D. C., Bria E., Tortora G. Chemotherapy Rechallenge or Reintroduction compared to Regorafenib or Trifluridine/Tipiracil for pretreated metastatic colorectal cancer patients: a PROpensity ScorE analysis of tReatment beYond secoNd line (PROSERpYNa Study) // Clinical Colorectal Cancer. 2025. Vol. 24. No. 1. pp. 1-100000.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.clcc.2024.06.002
UR - https://linkinghub.elsevier.com/retrieve/pii/S1533002824000574
TI - Chemotherapy Rechallenge or Reintroduction compared to Regorafenib or Trifluridine/Tipiracil for pretreated metastatic colorectal cancer patients: a PROpensity ScorE analysis of tReatment beYond secoNd line (PROSERpYNa Study)
T2 - Clinical Colorectal Cancer
AU - Calegari, M.A.
AU - Zurlo, I.V.
AU - Dell’Aquila, Emanuela
AU - BASSO, M.
AU - Orlandi, A
AU - Bensi, M.
AU - Camarda, F
AU - Anghelone, A
AU - Pozzo, Carmelo
AU - Sperduti, Isabella
AU - Salvatore, L
AU - SANTINI, D.
AU - Corsi, Domenico Cristiano
AU - Bria, E.
AU - Tortora, G.
PY - 2025
DA - 2025/03/01
PB - Elsevier
SP - 1-100000
IS - 1
VL - 24
PMID - 38969549
SN - 1533-0028
SN - 1938-0674
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Calegari,
author = {M.A. Calegari and I.V. Zurlo and Emanuela Dell’Aquila and M. BASSO and A Orlandi and M. Bensi and F Camarda and A Anghelone and Carmelo Pozzo and Isabella Sperduti and L Salvatore and D. SANTINI and Domenico Cristiano Corsi and E. Bria and G. Tortora},
title = {Chemotherapy Rechallenge or Reintroduction compared to Regorafenib or Trifluridine/Tipiracil for pretreated metastatic colorectal cancer patients: a PROpensity ScorE analysis of tReatment beYond secoNd line (PROSERpYNa Study)},
journal = {Clinical Colorectal Cancer},
year = {2025},
volume = {24},
publisher = {Elsevier},
month = {mar},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1533002824000574},
number = {1},
pages = {1--100000},
doi = {10.1016/j.clcc.2024.06.002}
}
MLA
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MLA Copy
Calegari, M.A., et al. “Chemotherapy Rechallenge or Reintroduction compared to Regorafenib or Trifluridine/Tipiracil for pretreated metastatic colorectal cancer patients: a PROpensity ScorE analysis of tReatment beYond secoNd line (PROSERpYNa Study).” Clinical Colorectal Cancer, vol. 24, no. 1, Mar. 2025, pp. 1-100000. https://linkinghub.elsevier.com/retrieve/pii/S1533002824000574.