A current view on Tau protein phosphorylation in Alzheimer's disease
Publication type: Journal Article
Publication date: 2021-08-01
scimago Q1
wos Q1
SJR: 2.540
CiteScore: 10.9
Impact factor: 5.2
ISSN: 09594388, 18736882
PubMed ID:
33892381
General Neuroscience
Abstract
The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites. Tau in healthy neurons carries multiple phosphate groups, mostly in its microtubule assembly domain. Elevated phosphorylation and aggregation of Tau are widely considered pathological hallmarks in Alzheimer's disease (AD) and other tauopathies, triggering the quest for Tau posttranslational modifications in the disease context. However, the phosphorylation patterns of physiological and pathological Tau are surprisingly similar and heterogenous, making it difficult to identify specific modifications as therapeutic targets and biomarkers for AD. We present a concise summary of - and view on - important previous and recent advances in Tau phosphorylation analysis in the context of AD.
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348
Total citations:
348
Citations from 2024:
208
(59.95%)
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GOST
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Wegmann S. et al. A current view on Tau protein phosphorylation in Alzheimer's disease // Current Opinion in Neurobiology. 2021. Vol. 69. pp. 131-138.
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Wegmann S., Biernat J., Mandelkow E. A current view on Tau protein phosphorylation in Alzheimer's disease // Current Opinion in Neurobiology. 2021. Vol. 69. pp. 131-138.
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TY - JOUR
DO - 10.1016/j.conb.2021.03.003
UR - https://doi.org/10.1016/j.conb.2021.03.003
TI - A current view on Tau protein phosphorylation in Alzheimer's disease
T2 - Current Opinion in Neurobiology
AU - Wegmann, Susanne
AU - Biernat, Jacek
AU - Mandelkow, E.-M.
PY - 2021
DA - 2021/08/01
PB - Elsevier
SP - 131-138
VL - 69
PMID - 33892381
SN - 0959-4388
SN - 1873-6882
ER -
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@article{2021_Wegmann,
author = {Susanne Wegmann and Jacek Biernat and E.-M. Mandelkow},
title = {A current view on Tau protein phosphorylation in Alzheimer's disease},
journal = {Current Opinion in Neurobiology},
year = {2021},
volume = {69},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.conb.2021.03.003},
pages = {131--138},
doi = {10.1016/j.conb.2021.03.003}
}