Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives
Juri M Timonen
1
,
Riina M. Nieminen
2
,
Outi Sareila
2
,
Antonis Goulas
2, 3
,
Lauri J. Moilanen
2
,
Matti Haukka
4
,
PIRJO VAINIOTALO
4
,
Eeva Moilanen
2
,
Paula H Aulaskari
4
Publication type: Journal Article
Publication date: 2011-09-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
21680063
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
A number of 7-hydroxycoumarins have been synthesised by Pechmann cyclisation using differently substituted resorcinols employing perchloric acid as the condensing agent. All the compounds have been characterised by analytical and spectroscopic methods. The anti-inflammatory properties were tested with LPS-induced inflammation in J774 macrophages. Expression of iNOS and COX-2 was determined by Western blot, NO by nitrite assay and IL-6 by ELISA analyses. Fifteen of the tested 7-hydroxycoumarins also inhibited IL-6 production but none of them had any major inhibitory effect on COX-2 expression.
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96
Total citations:
96
Citations from 2024:
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(12.5%)
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GOST
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Timonen J. M. et al. Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives // European Journal of Medicinal Chemistry. 2011. Vol. 46. No. 9. pp. 3845-3850.
GOST all authors (up to 50)
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Timonen J. M., Nieminen R., Sareila O., Goulas A., Moilanen L., Haukka M., VAINIOTALO P., Moilanen E., Aulaskari P. H. Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives // European Journal of Medicinal Chemistry. 2011. Vol. 46. No. 9. pp. 3845-3850.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2011.05.052
UR - https://doi.org/10.1016/j.ejmech.2011.05.052
TI - Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives
T2 - European Journal of Medicinal Chemistry
AU - Timonen, Juri M
AU - Nieminen, Riina M.
AU - Sareila, Outi
AU - Goulas, Antonis
AU - Moilanen, Lauri J.
AU - Haukka, Matti
AU - VAINIOTALO, PIRJO
AU - Moilanen, Eeva
AU - Aulaskari, Paula H
PY - 2011
DA - 2011/09/01
PB - Elsevier
SP - 3845-3850
IS - 9
VL - 46
PMID - 21680063
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2011_Timonen,
author = {Juri M Timonen and Riina M. Nieminen and Outi Sareila and Antonis Goulas and Lauri J. Moilanen and Matti Haukka and PIRJO VAINIOTALO and Eeva Moilanen and Paula H Aulaskari},
title = {Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives},
journal = {European Journal of Medicinal Chemistry},
year = {2011},
volume = {46},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.ejmech.2011.05.052},
number = {9},
pages = {3845--3850},
doi = {10.1016/j.ejmech.2011.05.052}
}
Cite this
MLA
Copy
Timonen, Juri M., et al. “Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives.” European Journal of Medicinal Chemistry, vol. 46, no. 9, Sep. 2011, pp. 3845-3850. https://doi.org/10.1016/j.ejmech.2011.05.052.