European Journal of Medicinal Chemistry

, volume 55 , pages 146-154

Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+

Hui-Juan Yu ¹

Yu Chen ^{2, 3}

Lin Yu ^{2, 3}

Zhifeng Hao ^{2, 3}

Li-Hua Zhou ^{2, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, No. 100 Waihuan Xi Road, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou 510006, PR China. |

Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, No. 100 Waihuan Xi Road, Guangzhou Higher Education Mega Center, Panyu District, Guangzhou 510006, PR China |

School of Life Science, Sun Yat-sen University, Guangzhou 510275, PR China |

Publication type: Journal Article

Publication date: 2012-09-01

Elsevier

European Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR: 1.142

CiteScore: 11.3

Impact factor: 5.9

ISSN: 02235234, 17683254

DOI: 10.1016/j.ejmech.2012.07.014

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PubMed ID: 22841281

Organic Chemistry

Drug Discovery

General Medicine

Pharmacology

Abstract

A new ruthenium complex [Ru(phen)(2)(mitatp)](2+) (phen = 1,10-phenanthroline, mitatp = 5-methoxy-isatino[1,2-b]-1,4,8,9-tetraazatriphenylene) has been synthesized and characterized. The interaction of the complex with DNA has been studied and the results indicate that [Ru(phen)(2)(mitatp)](2+) could efficiently photocleave pBR322 DNA under irradiation at visible light and the singlet oxygen (1)O(2) was proved to be reactive species in the photocleavage process. The cytotoxicity has also been evaluated by MTT method, and [Ru(phen)(2)(mitatp)](2+) shows prominent anticancer activity against various cancer cells. Live cell imaging study and flow cytometric analysis demonstrate that the complex could cross cell membrane accumulating in the nucleus and inducing cell death by induction of G0/G1 cells cycle arrest and apoptosis.

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Yu H. et al. Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+ // European Journal of Medicinal Chemistry. 2012. Vol. 55. pp. 146-154.

GOST all authors (up to 50) Copy

Yu H., Chen Yu., Yu L., Hao Z., Zhou L. Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+ // European Journal of Medicinal Chemistry. 2012. Vol. 55. pp. 146-154.

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RIS Copy

TY - JOUR

DO - 10.1016/j.ejmech.2012.07.014

UR - https://doi.org/10.1016/j.ejmech.2012.07.014

TI - Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+

T2 - European Journal of Medicinal Chemistry

AU - Yu, Hui-Juan

AU - Chen, Yu

AU - Yu, Lin

AU - Hao, Zhifeng

AU - Zhou, Li-Hua

PY - 2012

DA - 2012/09/01

PB - Elsevier

SP - 146-154

VL - 55

PMID - 22841281

SN - 0223-5234

SN - 1768-3254

ER -

BibTex

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BibTex (up to 50 authors) Copy

@article{2012_Yu,

author = {Hui-Juan Yu and Yu Chen and Lin Yu and Zhifeng Hao and Li-Hua Zhou},

title = {Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+},

journal = {European Journal of Medicinal Chemistry},

year = {2012},

volume = {55},

publisher = {Elsevier},

month = {sep},

url = {https://doi.org/10.1016/j.ejmech.2012.07.014},

pages = {146--154},

doi = {10.1016/j.ejmech.2012.07.014}

}

Publisher

Elsevier

Journal

European Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR

1.142

CiteScore

11.3

Impact factor

5.9

ISSN

02235234 (Print)

17683254 (Electronic)

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