Benzoxazoles and oxazolopyridines in medicinal chemistry studies
Publication type: Journal Article
Publication date: 2015-06-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
25487760
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
The benzoxazole heterocycle is often found in ligands targeting a plethora of receptors and enzymes. By analysis of published X-ray structures, this review aims at highlighting key interactions which the benzoxazole may engage in with its host protein. Furthermore, bioavailability, metabolism and the use of benzoxazole as a bioisostere are discussed. The review is extended to cover structure-activity relationship studies of 2-substituted benzoxazoles, 2-substituted oxazolopyridines, and in perspective, application of the recently published novel heterocycle oxazolopyrazine in medicinal chemistry studies.
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Metrics
147
Total citations:
147
Citations from 2024:
34
(23.12%)
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GOST
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Demmer C. S., Bunch L. Benzoxazoles and oxazolopyridines in medicinal chemistry studies // European Journal of Medicinal Chemistry. 2015. Vol. 97. pp. 778-785.
GOST all authors (up to 50)
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Demmer C. S., Bunch L. Benzoxazoles and oxazolopyridines in medicinal chemistry studies // European Journal of Medicinal Chemistry. 2015. Vol. 97. pp. 778-785.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ejmech.2014.11.064
UR - https://doi.org/10.1016/j.ejmech.2014.11.064
TI - Benzoxazoles and oxazolopyridines in medicinal chemistry studies
T2 - European Journal of Medicinal Chemistry
AU - Demmer, Charles S.
AU - Bunch, L.
PY - 2015
DA - 2015/06/01
PB - Elsevier
SP - 778-785
VL - 97
PMID - 25487760
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Demmer,
author = {Charles S. Demmer and L. Bunch},
title = {Benzoxazoles and oxazolopyridines in medicinal chemistry studies},
journal = {European Journal of Medicinal Chemistry},
year = {2015},
volume = {97},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.ejmech.2014.11.064},
pages = {778--785},
doi = {10.1016/j.ejmech.2014.11.064}
}