Experimental Eye Research, volume 134, pages 15-23

Metabolomic composition of normal aged and cataractous human lenses

Tsentalovich Yuri P ¹

Verkhovod Timofey D ²

Yanshole Vadim V ^{3, 4}

Kiryutin Alexey S. ²

Yanshole Lyudmila V ^{3, 4}

Fursova Anjella Zh ⁵

Stepakov Denis A ⁶

Novoselov Vladimir P ⁶

Sagdeev Renad Z ^{3, 4}

Hide authors affiliations Show authors affiliations: 6 affiliations

Novosibirsk State University , Pirogova 2 , Novosibirsk 630090 , Russia. |

International Tomography Center SB RAS, Institutskaya 3a, Novosibirsk 630090, Russia. |

International Tomography Center SB RAS, Institutskaya 3A, Novosibirsk, 630090, Russia |

⁴

Novosibirsk State University, Pirogova 2, Novosibirsk, 630090, Russia. |

⁵

Novosibirsk State Regional Clinical Hospital, Nemirovicha-Danchenko 130, Novosibirsk 630087, Russia. |

⁶

Novosibirsk Regional Clinical Bureau of Forensic Medical Examination, Nemirovicha-Danchenko 134, Novosibirsk 630087, Russia. |

Publication type: Journal Article

Publication date: 2015-05-01

Elsevier

Journal: Experimental Eye Research

Quartile SCImago

Quartile WOS

Impact factor: 3.4

ISSN: 00144835, 10960007

DOI: 10.1016/j.exer.2015.03.008

Copy DOI

Cellular and Molecular Neuroscience

Ophthalmology

Sensory Systems

Abstract

Quantitative metabolomic profiles of normal and cataractous human lenses were obtained with the combined use of high-frequency nuclear magnetic resonance (NMR) and high-performance liquid chromatography with high-resolution mass-spectrometric detection (LC-MS) methods. The concentration of more than fifty metabolites in the lens cortex and nucleus has been determined. For the majority of metabolites, their concentrations in the lens cortex and nucleus are similar, which confirms low metabolic activity in the lens core. The difference between the metabolite levels in the cortex and nucleus of the normal lens is observed for antioxidants and UV filters, which demonstrates the activity of redox processes in the lens. A huge difference is found between the metabolomic compositions of normal and age-matched cataractous lenses: the concentrations of almost all metabolites in the normal lens are higher than in the cataractous one. The most pronounced difference is observed for compounds playing a key role in the lens cell protection and metabolic activity, including antioxidants, UV filters, and osmolytes. The results obtained imply that the development of the age-related cataracts might originate from the metabolic dysfunction of the lens epithelial cells.

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Citations by journals

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Metabolomics	Metabolomics, 6, 9.84% Metabolomics 6 publications, 9.84%
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Journal of Photochemistry and Photobiology A: Chemistry	Journal of Photochemistry and Photobiology A: Chemistry, 2, 3.28% Journal of Photochemistry and Photobiology A: Chemistry 2 publications, 3.28%
Journal of Photochemistry and Photobiology B: Biology	Journal of Photochemistry and Photobiology B: Biology, 2, 3.28% Journal of Photochemistry and Photobiology B: Biology 2 publications, 3.28%
eLife	eLife, 2, 3.28% eLife 2 publications, 3.28%
EPMA Journal	EPMA Journal, 1, 1.64% EPMA Journal 1 publication, 1.64%
Journal of International Medical Research	Journal of International Medical Research, 1, 1.64% Journal of International Medical Research 1 publication, 1.64%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 1.64% International Journal of Molecular Sciences 1 publication, 1.64%
Antioxidants	Antioxidants, 1, 1.64% Antioxidants 1 publication, 1.64%
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Journal of Biological Chemistry	Journal of Biological Chemistry, 1, 1.64% Journal of Biological Chemistry 1 publication, 1.64%
Photochemistry and Photobiology	Photochemistry and Photobiology, 1, 1.64% Photochemistry and Photobiology 1 publication, 1.64%
Clinical and Experimental Ophthalmology	Clinical and Experimental Ophthalmology, 1, 1.64% Clinical and Experimental Ophthalmology 1 publication, 1.64%
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RSC Advances	RSC Advances, 1, 1.64% RSC Advances 1 publication, 1.64%
Ophthalmic Genetics	Ophthalmic Genetics, 1, 1.64% Ophthalmic Genetics 1 publication, 1.64%

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Citations by publishers

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Springer Nature	Springer Nature, 15, 24.59% Springer Nature 15 publications, 24.59%
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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 11, 18.03% Multidisciplinary Digital Publishing Institute (MDPI) 11 publications, 18.03%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 4, 6.56% Public Library of Science (PLoS) 4 publications, 6.56%
Wiley	Wiley, 4, 6.56% Wiley 4 publications, 6.56%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 4, 6.56% Royal Society of Chemistry (RSC) 4 publications, 6.56%
eLife Sciences Publications	eLife Sciences Publications, 2, 3.28% eLife Sciences Publications 2 publications, 3.28%
SAGE	SAGE, 1, 1.64% SAGE 1 publication, 1.64%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 1.64% American Society for Biochemistry and Molecular Biology 1 publication, 1.64%
Taylor & Francis	Taylor & Francis, 1, 1.64% Taylor & Francis 1 publication, 1.64%
Universita Palackeho Olomouc	Universita Palackeho Olomouc, 1, 1.64% Universita Palackeho Olomouc 1 publication, 1.64%
Spandidos Publications	Spandidos Publications, 1, 1.64% Spandidos Publications 1 publication, 1.64%
	2 4 6 8 10 12 14 16

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Tsentalovich Y. P. et al. Metabolomic composition of normal aged and cataractous human lenses // Experimental Eye Research. 2015. Vol. 134. pp. 15-23.

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Tsentalovich Y. P., Verkhovod T. D., Yanshole V. V., Kiryutin A. S., Yanshole L. V., Fursova A. Z., Stepakov D. A., Novoselov V. P., Sagdeev R. Z. Metabolomic composition of normal aged and cataractous human lenses // Experimental Eye Research. 2015. Vol. 134. pp. 15-23.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.exer.2015.03.008

UR - https://doi.org/10.1016%2Fj.exer.2015.03.008

TI - Metabolomic composition of normal aged and cataractous human lenses

T2 - Experimental Eye Research

AU - Tsentalovich, Yuri P

AU - Verkhovod, Timofey D

AU - Yanshole, Vadim V

AU - Kiryutin, Alexey S.

AU - Yanshole, Lyudmila V

AU - Fursova, Anjella Zh

AU - Stepakov, Denis A

AU - Novoselov, Vladimir P

AU - Sagdeev, Renad Z

PY - 2015

DA - 2015/05/01 00:00:00

PB - Elsevier

SP - 15-23

VL - 134

SN - 0014-4835

SN - 1096-0007

ER -

BibTex

Cite this

BibTex Copy

@article{2015_Tsentalovich,

author = {Yuri P Tsentalovich and Timofey D Verkhovod and Vadim V Yanshole and Alexey S. Kiryutin and Lyudmila V Yanshole and Anjella Zh Fursova and Denis A Stepakov and Vladimir P Novoselov and Renad Z Sagdeev},

title = {Metabolomic composition of normal aged and cataractous human lenses},

journal = {Experimental Eye Research},

year = {2015},

volume = {134},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016%2Fj.exer.2015.03.008},

pages = {15--23},

doi = {10.1016/j.exer.2015.03.008}

}

Found error?

Publisher

Elsevier

Journal

Experimental Eye Research

Quartile SCImago

Quartile WOS

Impact factor

3.4

ISSN

00144835 (Print)
10960007 (Electronic)

Labs

Laboratory of Proteomics and Metabolomics

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