Fitoterapia

, volume 81 , issue 6 , pages 475-479

Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity

Manmeet Kumar ¹

Preeti Rawat ¹

Mohammad Monirujjaman Khan ¹

Akhilesh K Tamarkar ²

Arvind K. Srivastava ²

Kamal R. Arya ³

Rakesh Maurya ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow-226 001, India |

Biochemistry Division, Central Drug Research Institute (CSIR), Lucknow 226 001, India |

Botany Division, Central Drug Research Institute, CSIR, Lucknow-226 001, India |

Publication type: Journal Article

Publication date: 2010-09-01

Elsevier

Fitoterapia

scimago Q2

wos Q3

SJR: 0.537

CiteScore: 3.9

Impact factor: 2.6

ISSN: 0367326X, 18736971

DOI: 10.1016/j.fitote.2010.01.011

Copy DOI

PubMed ID: 20079814

Drug Discovery

General Medicine

Pharmacology

Abstract

Phytochemical investigation of Dodecadenia grandiflora leaves led to the isolation and identification of three phenolic glycosides, designated 1-[(4'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (1), 1-[(6'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (2) and 1-[O-beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl]-oxy-2-phenol (3), along with nine known compounds. Compounds 1, 2, 5 and 9 exhibited significant glucose-6-phosphatase inhibitory activity (63.7, 66.9, 82.9 and 85.4%) with IC(50) values of 88.5, 81.0, 51 and 50 microM respectively. On the basis of biological results, a structure-activity relationship has been discussed.

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GOST Copy

Kumar M. et al. Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity // Fitoterapia. 2010. Vol. 81. No. 6. pp. 475-479.

GOST all authors (up to 50) Copy

Kumar M., Rawat P., Khan M. M., Tamarkar A. K., Srivastava A. K., Arya K. R., Maurya R. Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity // Fitoterapia. 2010. Vol. 81. No. 6. pp. 475-479.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.fitote.2010.01.011

UR - https://doi.org/10.1016/j.fitote.2010.01.011

TI - Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity

T2 - Fitoterapia

AU - Kumar, Manmeet

AU - Rawat, Preeti

AU - Khan, Mohammad Monirujjaman

AU - Tamarkar, Akhilesh K

AU - Srivastava, Arvind K.

AU - Arya, Kamal R.

AU - Maurya, Rakesh

PY - 2010

DA - 2010/09/01

PB - Elsevier

SP - 475-479

IS - 6

VL - 81

PMID - 20079814

SN - 0367-326X

SN - 1873-6971

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2010_Kumar,

author = {Manmeet Kumar and Preeti Rawat and Mohammad Monirujjaman Khan and Akhilesh K Tamarkar and Arvind K. Srivastava and Kamal R. Arya and Rakesh Maurya},

title = {Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity},

journal = {Fitoterapia},

year = {2010},

volume = {81},

publisher = {Elsevier},

month = {sep},

url = {https://doi.org/10.1016/j.fitote.2010.01.011},

number = {6},

pages = {475--479},

doi = {10.1016/j.fitote.2010.01.011}

}

MLA

Cite this

MLA Copy

Kumar, Manmeet, et al. “Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity.” Fitoterapia, vol. 81, no. 6, Sep. 2010, pp. 475-479. https://doi.org/10.1016/j.fitote.2010.01.011.

Publisher

Elsevier

Journal

Fitoterapia

scimago Q2

wos Q3

SJR

0.537

CiteScore

3.9

Impact factor

2.6

ISSN

0367326X (Print)

18736971 (Electronic)