Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea
Publication type: Journal Article
Publication date: 2014-04-01
scimago Q2
wos Q3
SJR: 0.537
CiteScore: 3.9
Impact factor: 2.6
ISSN: 0367326X, 18736971
PubMed ID:
24594242
Drug Discovery
General Medicine
Pharmacology
Abstract
Bioassay-guided fractionation of the ethanol extract of the Chinese folk medicine Crotalaria ferruginea led to the isolation of a new isoflavonoid, 4'-hydroxy-2'-methylalpinum-isoflavone (1), and eight known analogs (2-9). Their structures were elucidated by spectroscopic analysis. Compounds 1, 2, 5, and 8 showed inhibitory activities against phosphodiesterase-4 (PDE4), a therapeutic target of asthma, with IC50 values ranging from 2.57 to 8.94 μM. The possible action mechanism and the structure-activity relationship (SAR) of the active isoflavonoids were explored by using molecular docking and molecular dynamics (MD) simulation methods. Our study herein may explain the anti-inflammatory function of this plant in Chinese folk medicine.
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Total citations:
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Citations from 2025:
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GOST
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Liu Y. N. et al. Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea // Fitoterapia. 2014. Vol. 94. pp. 177-182.
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Liu Y. N., Huang Y. Y., Bao J. M., Cai Y. H., Guo Y. Q., Liu S. N., Luo H., Yin S. Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea // Fitoterapia. 2014. Vol. 94. pp. 177-182.
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RIS
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TY - JOUR
DO - 10.1016/j.fitote.2014.02.010
UR - https://doi.org/10.1016/j.fitote.2014.02.010
TI - Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea
T2 - Fitoterapia
AU - Liu, Ye Na
AU - Huang, Yi You
AU - Bao, Jing Mei
AU - Cai, Ying Hong
AU - Guo, Yan Qiong
AU - Liu, Shao Nan
AU - Luo, Haibin
AU - Yin, Sheng
PY - 2014
DA - 2014/04/01
PB - Elsevier
SP - 177-182
VL - 94
PMID - 24594242
SN - 0367-326X
SN - 1873-6971
ER -
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BibTex (up to 50 authors)
Copy
@article{2014_Liu,
author = {Ye Na Liu and Yi You Huang and Jing Mei Bao and Ying Hong Cai and Yan Qiong Guo and Shao Nan Liu and Haibin Luo and Sheng Yin},
title = {Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea},
journal = {Fitoterapia},
year = {2014},
volume = {94},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.fitote.2014.02.010},
pages = {177--182},
doi = {10.1016/j.fitote.2014.02.010}
}