Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects
Da Song Yang
1
,
Zi Lei Li
1
,
Wei-Bing Peng
2
,
Yong-Ping Yang
1
,
Xue Wang
2
,
Kechun Liu
2
,
Xiaoli Li
1
,
Wei-Lie Xiao
3
Тип публикации: Journal Article
Дата публикации: 2015-06-01
scimago Q2
wos Q3
БС2
SJR: 0.537
CiteScore: 3.9
Impact factor: 2.6
ISSN: 0367326X, 18736971
PubMed ID:
25861748
Drug Discovery
General Medicine
Pharmacology
Краткое описание
One rare flavonoid-diterpene heterodimer, denticulatain C (1), one modified geranyl-type side chain substituted flavonoid, denticulatain D (2) and one geranylated flavonoid, denticulatain E (3), as well as 11 known compounds (4-14) were isolated from the fronds of Macaranga denticulata. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 4 and 8 inhibited the proliferation of A-549 cell line with IC50 values of 48.6 and 20.2 μg/mL, respectively. Compounds 3, 6, and 8 exhibited significant antiangiogenic activity on a zebrafish model with IC50 values of 9.78, 0.34, and 2.55 μg/mL, respectively.
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ГОСТ |
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BibTex
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ГОСТ
Скопировать
Yang D. S. et al. Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects // Fitoterapia. 2015. Vol. 103. pp. 165-170.
ГОСТ со всеми авторами (до 50)
Скопировать
Yang D. S., Li Z. L., Peng W., Yang Y., Wang X., Liu K., Li X., Xiao W. Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects // Fitoterapia. 2015. Vol. 103. pp. 165-170.
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RIS
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TY - JOUR
DO - 10.1016/j.fitote.2015.04.001
UR - https://doi.org/10.1016/j.fitote.2015.04.001
TI - Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects
T2 - Fitoterapia
AU - Yang, Da Song
AU - Li, Zi Lei
AU - Peng, Wei-Bing
AU - Yang, Yong-Ping
AU - Wang, Xue
AU - Liu, Kechun
AU - Li, Xiaoli
AU - Xiao, Wei-Lie
PY - 2015
DA - 2015/06/01
PB - Elsevier
SP - 165-170
VL - 103
PMID - 25861748
SN - 0367-326X
SN - 1873-6971
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2015_Yang,
author = {Da Song Yang and Zi Lei Li and Wei-Bing Peng and Yong-Ping Yang and Xue Wang and Kechun Liu and Xiaoli Li and Wei-Lie Xiao},
title = {Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects},
journal = {Fitoterapia},
year = {2015},
volume = {103},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.fitote.2015.04.001},
pages = {165--170},
doi = {10.1016/j.fitote.2015.04.001}
}