Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
Lucie Cahlíková
1
,
Lucie Hulová
1
,
Martina Hrabinova
2
,
Jakub Chlebek
1
,
Anna Hošťálková
1
,
Markéta Adamcová
1
,
Marcela Šafratová
1
,
Daniel Jun
2
,
L. Opletal
1
,
Miroslav Ločárek
1
,
Katerina Macakova
1
2
Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Třebesšká 1575, 500 05 Hradec Králové, Czech Republic
|
Publication type: Journal Article
Publication date: 2015-06-01
scimago Q2
wos Q3
SJR: 0.537
CiteScore: 3.9
Impact factor: 2.6
ISSN: 0367326X, 18736971
PubMed ID:
25863351
Drug Discovery
General Medicine
Pharmacology
Abstract
Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues. It has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders and therefore may have important clinical implications. Thirty-one isoquinoline alkaloids of various structural types, previously isolated in our laboratory, were screened for their ability to inhibit prolyl oligopeptidase. Promising results have been showed by alkaloids californidine (IC50=55.6±3.5 μM), dihydrosanquinarine (IC50=99.1±7.6 μM), corypalmine (IC50=128.0±10.5 μM) and N-methyllaurotetanine (IC50=135.0±11.7 μM).
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28
Total citations:
28
Citations from 2024:
8
(28.57%)
Cite this
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RIS |
BibTex
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GOST
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Cahlíková L. et al. Isoquinoline alkaloids as prolyl oligopeptidase inhibitors // Fitoterapia. 2015. Vol. 103. pp. 192-196.
GOST all authors (up to 50)
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Cahlíková L., Hulová L., Hrabinova M., Chlebek J., Hošťálková A., Adamcová M., Šafratová M., Jun D., Opletal L., Ločárek M., Macakova K. Isoquinoline alkaloids as prolyl oligopeptidase inhibitors // Fitoterapia. 2015. Vol. 103. pp. 192-196.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.fitote.2015.04.004
UR - https://doi.org/10.1016/j.fitote.2015.04.004
TI - Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
T2 - Fitoterapia
AU - Cahlíková, Lucie
AU - Hulová, Lucie
AU - Hrabinova, Martina
AU - Chlebek, Jakub
AU - Hošťálková, Anna
AU - Adamcová, Markéta
AU - Šafratová, Marcela
AU - Jun, Daniel
AU - Opletal, L.
AU - Ločárek, Miroslav
AU - Macakova, Katerina
PY - 2015
DA - 2015/06/01
PB - Elsevier
SP - 192-196
VL - 103
PMID - 25863351
SN - 0367-326X
SN - 1873-6971
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Cahlíková,
author = {Lucie Cahlíková and Lucie Hulová and Martina Hrabinova and Jakub Chlebek and Anna Hošťálková and Markéta Adamcová and Marcela Šafratová and Daniel Jun and L. Opletal and Miroslav Ločárek and Katerina Macakova},
title = {Isoquinoline alkaloids as prolyl oligopeptidase inhibitors},
journal = {Fitoterapia},
year = {2015},
volume = {103},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.fitote.2015.04.004},
pages = {192--196},
doi = {10.1016/j.fitote.2015.04.004}
}