volume 130 pages 89-93

Hydroquinone and terpene glucosides from Leontopodium leontopodioides and their lipase inhibitory activity

Publication typeJournal Article
Publication date2018-10-01
scimago Q2
wos Q3
SJR0.537
CiteScore3.9
Impact factor2.6
ISSN0367326X, 18736971
Drug Discovery
General Medicine
Pharmacology
Abstract
Three new glucosides of hydroquinone, monoterpene, and megastigmane, benzyl 2,5-dihydroxybenzoate 5-O-β-d-glucopyranoside (isotrichocarpin, 1), (2S,3R)-3,7-dimethyl-6-octene-1,2,3-triol 2-O-β-d-glucopyranoside (leontopodioside D, 4), and (6R,7R,8R,9S)-6,9-epoxy-7,8-dihydroxymegastigman-4-en-3-one 8-O-β-d-glucopyranoside (leontopodioside E, 7) were isolated from the whole herbs of Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae), along with nebrodenside A (2), pungenin (3), betulalbuside A (5), geranyl O-β-d-glucopyranoside (6), and 3β-hydroxy-β-ionone 3-O-β-d-glucopyranoside (8). Their structure were determined by spectroscopic and chemical methods. All the known compounds were reported from this species for the first time. Compounds 2-6 showed potent in vitro pancreatic lipase inhibitory activity, suggesting their participation in the reductive effect of the herbs on triglyceride absorption.
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Gou P. et al. Hydroquinone and terpene glucosides from Leontopodium leontopodioides and their lipase inhibitory activity // Fitoterapia. 2018. Vol. 130. pp. 89-93.
GOST all authors (up to 50) Copy
Gou P., Xie H. Hydroquinone and terpene glucosides from Leontopodium leontopodioides and their lipase inhibitory activity // Fitoterapia. 2018. Vol. 130. pp. 89-93.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.fitote.2018.08.010
UR - https://doi.org/10.1016/j.fitote.2018.08.010
TI - Hydroquinone and terpene glucosides from Leontopodium leontopodioides and their lipase inhibitory activity
T2 - Fitoterapia
AU - Gou, Ping
AU - Xie, Hai-Hui
PY - 2018
DA - 2018/10/01
PB - Elsevier
SP - 89-93
VL - 130
PMID - 30145331
SN - 0367-326X
SN - 1873-6971
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Gou,
author = {Ping Gou and Hai-Hui Xie},
title = {Hydroquinone and terpene glucosides from Leontopodium leontopodioides and their lipase inhibitory activity},
journal = {Fitoterapia},
year = {2018},
volume = {130},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.fitote.2018.08.010},
pages = {89--93},
doi = {10.1016/j.fitote.2018.08.010}
}