Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats
Volha Zabela
1
,
Chethan Sampath
2
,
Mouhssin Oufir
1
,
Veronika D Butterweck
2
,
Matthias Hamburger
1
Publication type: Journal Article
Publication date: 2020-04-01
scimago Q2
wos Q3
SJR: 0.537
CiteScore: 3.9
Impact factor: 2.6
ISSN: 0367326X, 18736971
PubMed ID:
32097685
Drug Discovery
General Medicine
Pharmacology
Abstract
3,4-Dihydroxyphenylacetic acid (DOPAC) and 3-hydroxyphenylacetic acid (3-HPAA) are intestinal metabolites of the dietary flavonoid quercetin. DOPAC reportedly showed anxiolytic activity after i.p. administration in rats. The fate of these metabolites after consumption, and the pharmacological properties of 3-HPAA in the body are largely unknown. The aim of the current study was to characterize pharmacokinetic properties of DOPAC and 3-HPAA after intravenous bolus application in rats. UHPLC-MS/MS methods for quantification of DOPAC and 3-HPAA levels in lithium heparin Sprague Dawley rat plasma were developed and validated according to international regulatory guidelines. Non-compartmental and compartmental analyses were performed. Pharmacokinetic profiles of DOPAC and 3-HPAA followed a two-compartment body model, with a fast distribution into peripheral tissues (half-lives of 3.27–5.26 min) and rapid elimination from the body (half-lives of 18.4–33.3 min).
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Total citations:
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Zabela V. et al. Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats // Fitoterapia. 2020. Vol. 142. p. 104526.
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Zabela V., Sampath C., Oufir M., Butterweck V. D., Hamburger M. Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats // Fitoterapia. 2020. Vol. 142. p. 104526.
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TY - JOUR
DO - 10.1016/j.fitote.2020.104526
UR - https://doi.org/10.1016/j.fitote.2020.104526
TI - Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats
T2 - Fitoterapia
AU - Zabela, Volha
AU - Sampath, Chethan
AU - Oufir, Mouhssin
AU - Butterweck, Veronika D
AU - Hamburger, Matthias
PY - 2020
DA - 2020/04/01
PB - Elsevier
SP - 104526
VL - 142
PMID - 32097685
SN - 0367-326X
SN - 1873-6971
ER -
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BibTex (up to 50 authors)
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@article{2020_Zabela,
author = {Volha Zabela and Chethan Sampath and Mouhssin Oufir and Veronika D Butterweck and Matthias Hamburger},
title = {Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats},
journal = {Fitoterapia},
year = {2020},
volume = {142},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.fitote.2020.104526},
pages = {104526},
doi = {10.1016/j.fitote.2020.104526}
}