Free Radical Biology and Medicine, volume 208, pages 153-164
Hyperglycemia exacerbates ischemic stroke not through increased generation of hydrogen peroxide
Kotova Daria A
1
,
Ivanova Anna
1
,
Kelmanson Ilya
1, 3
,
Khramova Yulia V
1, 4
,
Tiaglik Alisa
1, 4, 5
,
Sudoplatov Mark A.
1, 6
,
Trifonova Arina P.
1, 7
,
Fedotova A. A.
1, 4
,
Morozova Kseniia
4
,
Katrukha Veronika A.
1, 4
,
Sergeeva Anastasia D
1, 4
,
Raevskii Roman I
1, 6
,
Pestriakova Mariia P.
1, 4
,
Solotenkov Maxim A
2
,
Stepanov Evgeny A.
2, 8
,
Tsopina Aleksandra S.
2
,
Moshchenko Aleksandr A
9
,
Shestopalova Milena
1, 10
,
Zalygin Anton
1, 10
,
Fedotov Ilya V.
1, 4
,
Fedotov Andrei B.
1, 4
,
Belousov Vsevolod V.
,
Semyanov Alexey
,
Brazhe Nadezda A.
,
Publication type: Journal Article
Publication date: 2023-11-01
Journal:
Free Radical Biology and Medicine
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.4
ISSN: 08915849, 18734596
Biochemistry
Physiology (medical)
Abstract
Diabetes is one of the significant risk factors for ischemic stroke. Hyperglycemia exacerbates the pathogenesis of stroke, leading to more extensive cerebral damage and, as a result, to more severe consequences. However, the mechanism whereby the hyperglycemic status in diabetes affects biochemical processes during the development of ischemic injury is still not fully understood. In the present work, we record for the first time the real-time dynamics of H2O2 in the matrix of neuronal mitochondria in vitro in culture and in vivo in the brain tissues of rats during development of ischemic stroke under conditions of hyperglycemia and normal glucose levels. To accomplish this, we used a highly sensitive HyPer7 biosensor and a fiber-optic interface technology. We demonstrated that a high glycemic status does not affect the generation of H2O2 in the tissues of the ischemic core, while significantly exacerbating the consequences of pathogenesis. For the first time using Raman microspectroscopy approach, we have shown how a sharp increase in the blood glucose level increases the relative amount of reduced cytochromes in the mitochondrial electron transport chain in neurons under normal conditions in awake mice.
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Free Radical Biology and Medicine
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Free Radical Biology and Medicine
3 publications, 100%
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Elsevier
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Elsevier
3 publications, 100%
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Kotova D. A. et al. Hyperglycemia exacerbates ischemic stroke not through increased generation of hydrogen peroxide // Free Radical Biology and Medicine. 2023. Vol. 208. pp. 153-164.
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Kotova D. A., Ivanova A., Pochechuev M. S., Kelmanson I., Khramova Y. V., Tiaglik A., Sudoplatov M. A., Trifonova A. P., Fedotova A. A., Morozova K., Katrukha V. A., Sergeeva A. D., Raevskii R. I., Pestriakova M. P., Solotenkov M. A., Stepanov E. A., Tsopina A. S., Moshchenko A. A., Shestopalova M., Zalygin A., Fedotov I. V., Fedotov A. B., Oleinikov V., Belousov V. V., Semyanov A., Brazhe N. A., Zheltikov A. M., Bilan D. S. Hyperglycemia exacerbates ischemic stroke not through increased generation of hydrogen peroxide // Free Radical Biology and Medicine. 2023. Vol. 208. pp. 153-164.
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TY - JOUR
DO - 10.1016/j.freeradbiomed.2023.08.004
UR - https://doi.org/10.1016%2Fj.freeradbiomed.2023.08.004
TI - Hyperglycemia exacerbates ischemic stroke not through increased generation of hydrogen peroxide
T2 - Free Radical Biology and Medicine
AU - Kotova, Daria A
AU - Ivanova, Anna
AU - Pochechuev, Matvei S
AU - Kelmanson, Ilya
AU - Khramova, Yulia V
AU - Tiaglik, Alisa
AU - Sudoplatov, Mark A.
AU - Trifonova, Arina P.
AU - Fedotova, A. A.
AU - Morozova, Kseniia
AU - Katrukha, Veronika A.
AU - Sergeeva, Anastasia D
AU - Raevskii, Roman I
AU - Pestriakova, Mariia P.
AU - Solotenkov, Maxim A
AU - Stepanov, Evgeny A.
AU - Tsopina, Aleksandra S.
AU - Moshchenko, Aleksandr A
AU - Shestopalova, Milena
AU - Zalygin, Anton
AU - Fedotov, Ilya V.
AU - Fedotov, Andrei B.
AU - Oleinikov, Vladimir
AU - Belousov, Vsevolod V.
AU - Semyanov, Alexey
AU - Brazhe, Nadezda A.
AU - Zheltikov, A M
AU - Bilan, Dmitry S.
PY - 2023
DA - 2023/11/01 00:00:00
PB - Elsevier
SP - 153-164
VL - 208
SN - 0891-5849
SN - 1873-4596
ER -
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@article{2023_Kotova,
author = {Daria A Kotova and Anna Ivanova and Matvei S Pochechuev and Ilya Kelmanson and Yulia V Khramova and Alisa Tiaglik and Mark A. Sudoplatov and Arina P. Trifonova and A. A. Fedotova and Kseniia Morozova and Veronika A. Katrukha and Anastasia D Sergeeva and Roman I Raevskii and Mariia P. Pestriakova and Maxim A Solotenkov and Evgeny A. Stepanov and Aleksandra S. Tsopina and Aleksandr A Moshchenko and Milena Shestopalova and Anton Zalygin and Ilya V. Fedotov and Andrei B. Fedotov and Vladimir Oleinikov and Vsevolod V. Belousov and Alexey Semyanov and Nadezda A. Brazhe and A M Zheltikov and Dmitry S. Bilan},
title = {Hyperglycemia exacerbates ischemic stroke not through increased generation of hydrogen peroxide},
journal = {Free Radical Biology and Medicine},
year = {2023},
volume = {208},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016%2Fj.freeradbiomed.2023.08.004},
pages = {153--164},
doi = {10.1016/j.freeradbiomed.2023.08.004}
}