Open Access
Advances in drug delivery systems, challenges and future directions
Tobechukwu Christian Ezike
1
,
Ugochukwu Solomon Okpala
1
,
Ufedo Lovet Onoja
1
,
Chinenye Princess Nwike
1
,
Emmanuel Chimeh Ezeako
1
,
Osinachi Juliet Okpara
1
,
Charles Chinkwere Okoroafor
1
,
Shadrach Chinecherem Eze
2
,
Onyinyechi Loveth Kalu
2
,
Ugochukwu Gideon Nwadike
1
,
John O. Ogbodo
1
,
Bravo Udochukwu Umeh
4
,
Emmanuel Chekwube Ossai
1
,
Bennett Chima Nwanguma
1
3
Federal Medical Center, Bida, Niger State, Nigeria
|
Publication type: Journal Article
Publication date: 2023-06-25
PubMed ID:
37416680
Multidisciplinary
Abstract
Advances in molecular pharmacology and an improved understanding of the mechanism of most diseases have created the need to specifically target the cells involved in the initiation and progression of diseases. This is especially true for most life-threatening diseases requiring therapeutic agents which have numerous side effects, thus requiring accurate tissue targeting to minimize systemic exposure. Recent drug delivery systems (DDS) are formulated using advanced technology to accelerate systemic drug delivery to the specific target site, maximizing therapeutic efficacy and minimizing off-target accumulation in the body. As a result, they play an important role in disease management and treatment. Recent DDS offer greater advantages when compared to conventional drug delivery systems due to their enhanced performance, automation, precision, and efficacy. They are made of nanomaterials or miniaturized devices with multifunctional components that are biocompatible, biodegradable, and have high viscoelasticity with an extended circulating half-life. This review, therefore, provides a comprehensive insight into the history and technological advancement of drug delivery systems. It updates the most recent drug delivery systems, their therapeutic applications, challenges associated with their use, and future directions for improved performance and use.
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Metrics
604
Total citations:
604
Citations from 2024:
558
(93%)
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Ezike T. C. et al. Advances in drug delivery systems, challenges and future directions // Heliyon. 2023. Vol. 9. No. 6. p. e17488.
GOST all authors (up to 50)
Copy
Ezike T. C., Okpala U. S., Onoja U. L., Nwike C. P., Ezeako E. C., Okpara O. J., Okoroafor C. C., Eze S. C., Kalu O. L., Odoh E. C., Nwadike U. G., Ogbodo J. O., Umeh B. U., Ossai E. C., Nwanguma B. C. Advances in drug delivery systems, challenges and future directions // Heliyon. 2023. Vol. 9. No. 6. p. e17488.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.heliyon.2023.e17488
UR - https://doi.org/10.1016/j.heliyon.2023.e17488
TI - Advances in drug delivery systems, challenges and future directions
T2 - Heliyon
AU - Ezike, Tobechukwu Christian
AU - Okpala, Ugochukwu Solomon
AU - Onoja, Ufedo Lovet
AU - Nwike, Chinenye Princess
AU - Ezeako, Emmanuel Chimeh
AU - Okpara, Osinachi Juliet
AU - Okoroafor, Charles Chinkwere
AU - Eze, Shadrach Chinecherem
AU - Kalu, Onyinyechi Loveth
AU - Odoh, Evaristus Chinonso
AU - Nwadike, Ugochukwu Gideon
AU - Ogbodo, John O.
AU - Umeh, Bravo Udochukwu
AU - Ossai, Emmanuel Chekwube
AU - Nwanguma, Bennett Chima
PY - 2023
DA - 2023/06/25
PB - Elsevier
SP - e17488
IS - 6
VL - 9
PMID - 37416680
SN - 2405-8440
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Ezike,
author = {Tobechukwu Christian Ezike and Ugochukwu Solomon Okpala and Ufedo Lovet Onoja and Chinenye Princess Nwike and Emmanuel Chimeh Ezeako and Osinachi Juliet Okpara and Charles Chinkwere Okoroafor and Shadrach Chinecherem Eze and Onyinyechi Loveth Kalu and Evaristus Chinonso Odoh and Ugochukwu Gideon Nwadike and John O. Ogbodo and Bravo Udochukwu Umeh and Emmanuel Chekwube Ossai and Bennett Chima Nwanguma},
title = {Advances in drug delivery systems, challenges and future directions},
journal = {Heliyon},
year = {2023},
volume = {9},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.heliyon.2023.e17488},
number = {6},
pages = {e17488},
doi = {10.1016/j.heliyon.2023.e17488}
}
Cite this
MLA
Copy
Ezike, Tobechukwu Christian, et al. “Advances in drug delivery systems, challenges and future directions.” Heliyon, vol. 9, no. 6, Jun. 2023, p. e17488. https://doi.org/10.1016/j.heliyon.2023.e17488.
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